When the Denver Broncos traded to acquire the rights for head coach Sean Payton from the Saints, Broncos fans expected a revitalized offense. It was a disappointing start to Russell Wilson's second year in Denver and first working with Payton, but there have been signs of improvement over the last few weeks. The Broncos enter Monday Night Football against the Buffalo Bills to wrap up the Week 10 NFL schedule on a two-game winning streak, including a 24-9 win over the Chiefs last week. Broncos running back Javonte Williams is averaging 83.5 rushing yards over the last two games, so should you consider including him in Monday Night Football NFL player props?

Bills running back James Cook hasn't performed as many expected him to entering the season, as he's averaging 80.8 total yards. Should you fade Cook when making Monday Night Football NFL prop bets or could a matchup against the Broncos and their 32nd-ranked defense for yards and points allowed be the answer to turn around his struggles? Before betting any NFL props for Monday Night Football in Week 10 or entering selections on sites like PrizePicks, you need to see the Broncos vs. Bills NFL prop predictions from the SportsLine AI PickBot.

Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each player prop. The AI predictions are determined by statistically learning from each player's historical data then quantitatively evaluating the strength of the opponents defense by assigning a numeric value out of 100 called a matchup score. 

Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see a 5-star rating on an over bet if a player is facing a poor defense, their prediction differs from the line and there are favorable odds.

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In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. So far this season, SportsLine's AI PickBot has hit a whopping 365 4.5- and 5-star prop picks. Anyone who has followed it is way up.

For Bills vs. Broncos on Monday Night Football, the AI PickBot has evaluated the NFL player prop odds and provided Broncos vs. Bills prop picks for every available prop market. You can only see the AI player prop predictions for Buffalo vs. Denver here.

Top NFL player prop bets for Broncos vs. Bills

After analyzing Bills vs. Broncos and examining the dozens of NFL player props, the AI PickBot says Bills wide receiver Stefon Diggs goes over 86.5 receiving yards. The 29-year-old has been Josh Allen's favorite target since Diggs was acquired from the Vikings before the 2020 season. Diggs, who was fifth in the NFL in targets last season, is tied with Tyreek Hill for the most targets (97) in the league this year. The three-time Pro Bowler is third in receiving yards (834) and is averaging 92.7 yards per game.

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Any concern over potential riffs between Allen and Diggs over a sideline outburst during last year's playoffs has died down, in large part due to their undeniable connection on the field. Diggs has at least seven targets in each game and has at least 100 yards in five of nine contests. The Broncos are allowing the most points and yards per game in the NFL this year and they've been most susceptible through the passing attack. Denver has allowed the sixth-most passing yards per game (251.8) this season. Diggs is receiving a 31.6% target share from Allen, a key reason why the model is projecting Diggs to record 107.9 yards, safely placing him above the current prop total of 86.5 and making it one of the 4.5-star plays on Monday Night Football. See more NFL props here.

How to make NFL player prop bets for Denver vs. Buffalo

In addition, the AI PickBot says another star sails past his total and has 14 other NFL props rated four stars or better. You need to see the AI PickBot's analysis before making any Bills vs. Broncos prop bets for Monday Night Football.

Which Broncos vs. Bills prop bets should you target for Monday Night Football? Visit SportsLine now to see the top Bills vs. Broncos props, all from the brand-new SportsLine AI PickBot that has nailed 365 top-rated picks this season.

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