| All Running Backs vs Cardinals | ||||||||||||
| Rushing | Receiving | |||||||||||
| Week | Player | Att | Yd | Avg | TD | Targt | Recpt | Yd | Avg | TD | FL | FPTS |
| 1 | Cook, James, BUF | 19 | 71 | 3.74 | 0 | 3 | 3 | 32 | 10.67 | 0 | 0 | 10 |
| 1 | Davis, Ray, BUF | 3 | 13 | 4.33 | 0 | 1 | 1 | 14 | 14.00 | 0 | 0 | 2 |
| 1 | Johnson, Ty, BUF | 2 | 7 | 3.50 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| 2 | Williams, Kyren, LAR | 12 | 25 | 2.08 | 1 | 5 | 4 | 27 | 6.75 | 0 | 0 | 10 |
| 2 | Corum, Blake, LAR | 8 | 28 | 3.50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 |
| 2 | Rivers, Ronnie, LAR | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0.00 | 0 | 0 | 0 |
| 3 | Montgomery, David, DET | 23 | 105 | 4.57 | 1 | 3 | 3 | 17 | 5.67 | 0 | 0 | 17 |
| 3 | Gibbs, Jahmyr, DET | 16 | 83 | 5.19 | 0 | 0 | 0 | 20 | 0 | 1 | 0 | 16 |
| 4 | McNichols, Jeremy, WAS | 8 | 68 | 8.50 | 2 | 1 | 1 | 6 | 6.00 | 0 | 0 | 18 |
| 4 | Robinson Jr., Brian, WAS | 21 | 101 | 4.81 | 1 | 3 | 3 | 12 | 4.00 | 0 | 0 | 17 |
| 5 | Mason, Jordan, SF | 14 | 89 | 6.36 | 0 | 1 | 1 | 9 | 9.00 | 0 | 1 | 6 |
| 5 | Guerendo, Isaac, SF | 5 | 22 | 4.40 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 |
| 6 | Jacobs, Josh, GB | 18 | 62 | 3.44 | 0 | 3 | 3 | 28 | 9.33 | 0 | 0 | 8 |
| 6 | Wilson, Emanuel, GB | 7 | 54 | 7.71 | 0 | 2 | 1 | 19 | 19.00 | 0 | 0 | 6 |
| 6 | Brooks, Christopher, GB | 4 | 21 | 5.25 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 |
| 7 | Dobbins, J.K., LAC | 14 | 40 | 2.86 | 0 | 3 | 3 | 26 | 8.67 | 0 | 0 | 6 |
| 7 | Vidal, Kimani, LAC | 3 | 10 | 3.33 | 0 | 1 | 1 | 9 | 9.00 | 0 | 0 | 1 |
| 7 | Haskins, Hassan, LAC | 2 | 2 | 1.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 8 | Achane, De'Von, MIA | 10 | 97 | 9.70 | 0 | 8 | 6 | 50 | 8.33 | 1 | 0 | 20 |
| 8 | Mostert, Raheem, MIA | 9 | 19 | 2.11 | 2 | 2 | 1 | 11 | 11.00 | 0 | 0 | 14 |
| 8 | Ingold, Alec, MIA | 1 | 3 | 3.00 | 0 | 3 | 3 | 19 | 6.33 | 0 | 0 | 1 |
| 8 | Wright, Jaylen, MIA | 2 | 18 | 9.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
| 9 | Swift, D'Andre, CHI | 16 | 51 | 3.19 | 0 | 6 | 6 | 31 | 5.17 | 0 | 0 | 8 |
| 9 | Johnson, Roschon, CHI | 3 | 13 | 4.33 | 0 | 3 | 2 | 8 | 4.00 | 0 | 0 | 1 |
| 10 | Hall, Breece, NYJ | 10 | 52 | 5.20 | 0 | 4 | 4 | 31 | 7.75 | 0 | 0 | 8 |
| 10 | Allen, Braelon, NYJ | 7 | 27 | 3.86 | 0 | 1 | 1 | 7 | 7.00 | 0 | 0 | 2 |
| 10 | Davis, Isaiah, NYJ | 0 | 0 | 0 | 0 | 1 | 1 | 10 | 10.00 | 0 | 0 | 1 |
| 12 | Walker III, Kenneth, SEA | 16 | 41 | 2.56 | 0 | 6 | 4 | 52 | 13.00 | 0 | 0 | 9 |
| 12 | Charbonnet, Zach, SEA | 6 | 22 | 3.67 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 |
| 13 | Jones, Aaron, MIN | 5 | 22 | 4.40 | 0 | 4 | 3 | 6 | 2.00 | 1 | 1 | 6 |
| 13 | Akers, Cam, MIN | 4 | 22 | 5.50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 |
| 13 | Chandler, Ty, MIN | 2 | 2 | 1.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 14 | Charbonnet, Zach, SEA | 22 | 134 | 6.09 | 2 | 7 | 7 | 59 | 8.43 | 0 | 0 | 30 |
| 14 | McIntosh, Kenny, SEA | 7 | 38 | 5.43 | 0 | 2 | 2 | 7 | 3.50 | 0 | 0 | 3 |
| 14 | Holani, George, SEA | 0 | 0 | 0 | 0 | 1 | 1 | -1 | -1.00 | 0 | 0 | 0 |
| 15 | Stevenson, Rhamondre, NE | 13 | 69 | 5.31 | 0 | 1 | 1 | 16 | 16.00 | 0 | 0 | 7 |
| 15 | Gibson, Antonio, NE | 7 | 33 | 4.71 | 0 | 2 | 2 | 31 | 15.50 | 0 | 0 | 6 |
| 16 | Hubbard, Chuba, CAR | 25 | 152 | 6.08 | 2 | 5 | 4 | 13 | 3.25 | 0 | 0 | 28 |
| 16 | Blackshear, Raheem, CAR | 3 | 13 | 4.33 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
| 16 | Boone, Mike, CAR | 1 | 1 | 1.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |