The No. 8 Oregon Ducks (3-0) will make their Big Ten debut when they go on the road to face the UCLA Bruins (1-2) on Saturday night. Oregon is coming off its best performance of the season, cruising to a 49-14 win at Oregon State its last time out. UCLA opened the campaign with a win over Hawaii before losing to Indiana and then-No. 16 LSU in its following games. The Ducks have won 10 of the last 11 meetings between these former Pac-12 rivals. 

Kickoff is set for 11 p.m. ET on Saturday at Rose Bowl. Oregon is favored by 25.5 points in the latest UCLA vs. Oregon odds, while the over/under is 55.5 points, per SportsLine consensus. Before entering any Oregon vs. UCLA picks, you'll want to see the college football predictions from the model at SportsLine.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of well over $2,000 for $100 players on its top-rated college football picks against the spread. It is also coming off a profitable 13-9 season on top-rated spread picks. Anyone who has followed it has seen strong returns.

The model has set its sights on Oregon vs. UCLA. You can head to SportsLine to see its picks. Here are several college football betting lines for the game:

  • UCLA vs. Oregon spread: Oregon -25.5
  • UCLA vs. Oregon over/under: 55.5 points
  • UCLA vs. Oregon money line: Oregon -3448, UCLA +1333
  • UCLA vs. Oregon picks: See picks here

Why UCLA can cover

UCLA is coming off a road loss at then-No. 16 LSU, but it covered the spread as a 21.5-point underdog. Senior quarterback Ethan Garbers completed 22 of 36 passes for 273 yards and two touchdowns in a game that was tied 17-17 at halftime. The Bruins are playing under first-year head coach DeShaun Foster, who was a former star running back at the school. 

They have converted just 3 of 9 red-zone opportunities into touchdowns, while their opponents are 8 of 12. This gives UCLA a chance to improve in both categories, which would keep this game closer than expected. The Bruins have won nine of their last 12 games in September. See which team to pick here. 

Why Oregon can cover

Oregon has dominated this head-to-head series, winning four in a row and 10 of the last 11 meetings. The Ducks are 15-3 in the 18 contests since 2000, including a 45-30 win in the most recent matchup (2022). They are coming off a 49-14 win at Oregon State, as quarterback Dillon Gabriel completed 20 of 24 passes for 291 yards and two touchdowns. 

The Ducks finished with 546 yards of total offense in that lopsided victory. Gabriel leads the nation with an 84% completion percentage and is the only FBS quarterback above 80%. He has 16,865 total yards in his career, putting him just 135 yards short of joining Case Keenum as the only players in NCAA history to reach the 17,000-yard mark. See which team to pick here. 

How to make UCLA vs. Oregon picks

The model has simulated Oregon vs. UCLA 10,000 times and the results are in. The model is leaning Over, and it's also generated a point-spread pick that is hitting in nearly 60% of simulations. You can only see the pick at SportsLine.

So who wins UCLA vs. Oregon, and which side of the spread is hitting nearly 60% of the time? Visit SportsLine now to see which side of the Oregon vs. UCLA spread to jump on, all from the advanced computer model that's up well over $2,000 on its top-rated college football spread picks since its inception, and find out.