College football fans will have plenty to keep them busy over the weekend, as Saturday's schedule will last for quite a while. One of the early afternoon matchups on tap will feature No. 17 Indiana and No. 18 Iowa. The Hoosiers shocked the world with an impressive 6-2 campaign in 2020 en route to the Gator Bowl. They'll visit a Hawkeyes team that also went 6-2 last year. Both ranked squads are threats to take home a win.

Kickoff at Kinnick Stadium is set for 3:30 p.m. ET, and the Hawkeyes are 3.5-point favorites in the latest Indiana vs. Iowa odds at Caesars Sportsbook. The over-under is set at 46. Before entering any Indiana vs. Iowa picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of over $3,600 for $100 players on its top-rated college football picks against the spread. It also enters Week 1 of the 2021 season on a 57-37 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Iowa vs. Indiana. You can head to SportsLine to see its picks. Here are several college football odds for Indiana vs. Iowa:

  • Iowa vs. Indiana spread: Iowa -3.5
  • Iowa vs. Indiana over-under: 46 points

What you need to know about the Indiana Hoosiers 

A big part of Indiana's breakthrough season last year was the play of quarterback Michael Penix Jr. He would have easily been named All-Big Ten first-team if not for the presence of Justin Fields. Penix still made the second team thanks to 14 touchdowns compared to just four interceptions. He tore his ACL in November but will start just 10 months later in this early-season conference battle.

Coach Tom Allen also fielded a top-20 scoring defense. That side of the ball is led by senior LB Micah McFadden who filled up the box score last year. McFadden led the Big Ten in sacks (six) while also finishing second in solo tackles (45) and second in interceptions (two). 

What you need to know about the Iowa Hawkeyes

Indiana won't be an easy team to cover the spread against, but Iowa can get it done. While the Hoosiers are 5-0 against the spread in their last five road games, the Hawkeyes are 5-0 straight up in their previous five games. Iowa still has several key pieces from last year that could give Indiana trouble.

Quarterback Spencer Petras and lead running back Tyler Goodson are among the home team's returning starters. Over half of last year's starters are back on both sides of the ball. Indiana has a heap of starters coming back too. Penix Jr. is somewhat of a question mark for Indiana after suffering a season-ending ACL tear last year. If he has to shake off the rust after missing spring practice, Iowa could have an advantage.

How to make Indiana vs. Iowa picks

The model has simulated Iowa vs. Indiana 10,000 times and the results are in. The model is leaning under on the total, and it's also generated a point-spread pick that hits in more than 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Indiana vs. Iowa? And which side of the spread hits over 50 percent of the time? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.