The No. 5 Clemson Tigers face a stiff test on Saturday afternoon at Memorial Stadium. Clemson hosts the No. 14 Syracuse Orange in an ACC showdown, with both teams entering with unbeaten records. Syracuse is 6-0 and 3-0 in conference play, while Clemson is 7-0 and 5-0 against ACC foes. The Tigers also have an active 37-game home winning streak, and Clemson is 8-2 all-time against Syracuse.

Kickoff is set for noon ET. Caesars Sportsbook lists the Tigers as 14-point home favorites. The total number of points Vegas thinks will be scored, or the over/under, is 50 in the latest Clemson vs. Syracuse odds. Before finalizing any Syracuse vs. Clemson picks, you need to see the college football predictions and betting advice from SportsLine's advanced computer model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Syracuse vs. Clemson and just locked in its picks and CFB predictions. You can head to SportsLine now to see the model's picks. Now, here are several college football odds and betting lines for Clemson vs. Syracuse:

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  • Clemson vs. Syracuse spread: Clemson -14
  • Clemson vs. Syracuse over/under: 50 points 
  • Clemson vs. Syracuse money line: Clemson -600, Syracuse +430
  • SYR: The Orange are 5-1 against the spread in 2022 
  • CLEM: The Tigers are 4-3 against the spread in 2022 
  • Clemson vs. Syracuse picks: See picks here

Why Syracuse can cover

Syracuse's defense has been excellent this season, but the Orange also have top-flight offensive indicators. The Orange are in the top five of the ACC with 188.5 rushing yards per game, averaging 4.9 yards per carry. Syracuse is also generating 9.3 yards per pass attempt with 12 passing touchdowns and three interceptions. The Orange keep the chains moving by converting 45.5% of third down opportunities, and quarterback Garrett Shrader is in the top four of the ACC in passing yards, yards per attempt, completion rate and passing touchdowns. 

Running back Sean Tucker is also a standout with 644 rushing yards in six games, and he is averaging 5.2 yards per carry to go along with 23 receptions for 198 yards. On the other side of the ball, Syracuse leads the ACC in scoring defense (13.2 points per game), total defense (268.8 yards per game), passing defense (173.8 yards per game) and plays allowed of 20 yards or more (eleven). The Orange are excellent against the run, giving up 95.0 yards per game and 3.2 yards per carry, and Syracuse also has 17 sacks in only six games.

Why Clemson can cover

Clemson continues to be an excellent defensive team. The Tigers have the best rushing defense in the ACC, giving up 82.7 yards per game and 2.8 yards per carry. That helps Clemson to hold opponents to 19.7 points per game, and Clemson is in the top five of the ACC in total defense, yielding 338.4 total yards per game. Clemson gives up only 6.4 yards per pass attempt with 17 sacks, and the Tigers put consistent pressure on opponents. 

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Clemson has the longest winning streak in FBS with 13 consecutive victories, and the Tigers also bring an efficient and effective offense to the table. Dabo Swinney's club has 18 passing touchdowns and only two interceptions this season, ranking No. 3 in the ACC with 38.6 points per game. Clemson is elite on third down, converting 50.5% of opportunities, and the Tigers have a balanced receiving corps that includes four players with at least 215 receiving yards and seven players with at least 120 receiving yards in 2022.

How to make Syracuse vs. Clemson picks

SportsLine's model is leaning Over on the point total, with both teams projected to have a leading rusher with at least 70 yards. The model also says one side of the spread hits in almost 60% of simulations. You can only see the model's CFB picks at SportsLine.

So who wins Syracuse vs. Clemson? And which side of the spread hits in almost 60% of simulations? Visit SportsLine now to see which side of the Syracuse vs. Clemson spread you need to jump on Saturday, all from the model that has crushed its college football picks, and find out.  

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