The No. 1 Alabama Crimson Tide are fresh off a thrilling win over the No. 5 Georgia Bulldogs and Jalen Milroe has established himself as one of the top Heisman Trophy contenders. The Tide are set to hit the road to take on the Vanderbilt Commodores as part of the Week 6 college football schedule. Alabama is favored by 22.5 points in the Week 6 college football odds, and the over/under for that game is 54.5 points. Should you back Alabama when making your Week 6 college football picks and Week 6 college football bets?
Other games of note include Arkansas vs. Tennessee (-14), Missouri vs. Texas A&M (-2.5), Iowa vs. Ohio State (-18.5), and Michigan vs. Washington (-1.5) in a rematch of last year's national championship game. Should you target any of those games in your Week 6 college football betting strategy? Before locking in any Week 6 college football picks on those games or others, be sure to see the college football betting guide from legendary Vegas handicapper Bruce Marshall.
For years Vegas-based Marshall was synonymous with The Gold Sheet, the famed sports betting newsletter. With a background in play-by-play work and sports information while in college, Marshall joined TGS in 1981 when hired by the legendary Mort Olshan and served as executive editor for many years.
An in-demand guest on numerous sports talk radio and TV shows across the country, Bruce's vast array of editorial work has been featured in the Las Vegas Review-Journal, the New York Post and many other outlets. He has won various handicapping titles and also is working on several book projects. Bruce also enters the Week 6 college football schedule on a 17-7 roll (+923) on his official SportsLine college football spread picks.
Now, using his Tech Corner technique that evaluates all the trends and the latest college football odds, Marshall has turned his attention to college football betting for Week 6 and revealed picks for each matchup. Head to SportsLine to see every pick.
Top college football predictions for Week 6
One of the top college football picks Marshall is recommending for Week 6: He's backing the red-hot Indiana Hoosiers to cover the 13.5-point spread against Northwestern in a 3:30 p.m. ET matchup. The Hoosiers have been one of the biggest surprises of the 2024 college football season thus far, and have won all five of their games in blowout fashion. In its last outing, Indiana dominated Maryland, winning 42-28.
Quarterback Kurtis Rourke has been outstanding for Indiana in 2024. The senior signal caller has thrown for 1,372 yards, 11 touchdowns and two interceptions. He's also rushed for 46 yards and two scores. Rourke has the skillset to give the Northwestern defense fits all game. Marshall Likes the Hoosiers to cover in addition to the Over (41) here. See which other picks to make here.
How to make college football picks for Week 6
Marshall has evaluated every other matchup and he's found an alarming 23-5 betting trend you need to know this week. Get betting analysis for each matchup at SportsLine.
So what college football picks can you make with confidence, and what alarming trend do you need to know about? Check out the latest college football odds below, then visit SportsLine to see which teams to back, all from the legendary Vegas expert who has won multiple handicapping titles, and find out.
Week 6 college football odds
See full Week 6 college football picks, odds and predictions here.
Saturday, Oct. 5
Missouri at Texas A&M (-2.5, 47.5)
UCLA at Penn State (-28.5, 46.5)
Ole Miss at South Carolina (+9.5, 53.5)
Iowa at Ohio State (-18.5, 45.5)
Alabama at Vanderbilt (+22.5, 54.5)
Clemson at Florida State (+15.5, 46.5)
Tennessee at Arkansas (+14, 57.5)
Baylor at Iowa State (-12.5, 45)
Michigan at Washington (-1.5, 41.5)
Miami at California (+10, 54)
Texas Tech at Arizona (-6.5, 64)