The 2022 U.S. Open gets underway on Monday (11 a.m. ET) at the USTA Billie Jean King National Tennis Center in New York. On the men's side, Rafael Nadal is the center of attention, seeking his 23rd grand slam title and fifth win at the event. Top-ranked Daniil Medvedev is also in action, looking to repeat after winning the 2021 title. The field is deep and talented, though both Roger Federer and Novak Djokovic are absent from the festivities.
Medvedev is the favorite at +225 (risk $100 to win $225) in the latest 2022 U.S. Open men's singles odds at Caesars Sportsbook. Nadal is listed at +400 to claim another title. Elsewhere, Carlos Alcaraz is listed at +500, with Nick Kyrgios at +900 and Stefanos Tsitsipas at +1400. Before making any 2022 U.S. Open picks on the men's side, you need to see who SportsLine tennis Sean Calvert is backing.
Calvert is the handicapper who called Stan Wawrinka winning the 2014 Australian Open at 60-1, the last Australian title won by someone other than Djokovic or Federer. In 2019, Calvert took down a huge score on Dominic Thiem winning Indian Wells at 80-1.
Now, Calvert has scrutinized the latest U.S. Open 2022 odds and released his coveted best bets to win it all. He's sharing all of his picks and analysis at SportsLine.
Top 2022 U.S. Open men's predictions
For a long time in the tennis world, three names have ruled on the men's side in Djokovic, Federer and Nadal. Djokovic and Federer are unavailable for the 2022 U.S. Open and, while Nadal is not the No. 1 seed, he is the biggest and most attractive name before the tournament begins. Nadal is a 22-time grand slam champion, No. 1 all-time, and he has four U.S. Open titles to go along with two grand tournament titles this year.
As such, many will rush to back him in a futures setting, but Calvert is fading Nadal at his current price. Nadal's injury questions are of concern, as he has appeared in only one match since withdrawing from Wimbledon with an abdominal injury. He lost that match to Borna Coric following a six-week layoff, and Nadal also has a lingering knee issue that could cause problems in New York.
Nadal also could face challenging opponents like Alcatraz or Medvedev late in the tournament, making his price less enticing at this early stage. You can see who to back here.
How to make 2022 U.S. Open men's picks
Calvert has a full preview with picks you have to see, including a pair of longshot picks with great value. He's only sharing his analysis, and all of his U.S. Open picks and best bets, at SportsLine.
So who wins the 2022 U.S. Open? And which enormous longshots could take the crown? Visit SportsLine now to see Calvert's bets for the 2022 U.S. Open, all from the renowned tennis expert with several high-profile future wins, and find out.
