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In a match that's worthy of being a grand slam final, tennis greats Rafael Nadal and Novak Djokovic collide on Wednesday in a blockbuster quarterfinal in the 2022 French Open at Roland Garros in Paris. This will be the first match in tennis history featuring two players with 20 grand slam titles; Nadal owns a record 21, one more than Djokovic and Roger Federer. This will also be the 59th meeting between the two rivals; no tennis rivalry has been played more often. The match will not begin before 2:45 p.m. ET.

For Tuesday, Djokovic is a -250 favorite (risk $250 to win $100) in the latest Djokovic vs. Nadal odds from Caesars Sportsbook, while Nadal is a +190 underdog. The over-under for total games is 36.5. Before making any 2022 French Open picks, be sure to see the latest tennis predictions from SportsLine's Sean Calvert

Calvert is the handicapper who called Stan Wawrinka winning the 2014 Australian Open at 60-1. In the Miami Open in 2018, he did even better, correctly calling 100-1 long shot John Isner to win the title. And in 2019, Calvert took down a huge score on Dominic Thiem winning Indian Wells at 80-1. Anyone following his picks is way up.

Now, Calvert has locked in on the 2022 French Open men's quarterfinal matchup featuring Djokovic vs. Nadal and revealed his best bets. Head to SportsLine to see them.

Top Djokovic vs. Nadal predictions

The top seed in the tournament, Djokovic has been dominant on the clay in his last two tournaments. Across his last nine matches in Rome and Paris, Djokovic has not even given up a set. Through four matches at Roland Garros, he has given up more than three games in a set only once: in the second round against Alex Molcan, who extended Djokovic to a third set tiebreaker.

Djokovic enters Tuesday's match with the edge in serving, on paper. So far in this tournament, the 35-year-old Serbian has hit 31 aces, has landed 71 percent of his first serves in and has converted 77 percent of points behind his first serve. By contrast, Nadal has just seven aces, has landed 65 percent of his first serves in and has converted 73 percent of points behind his first serve.

However, Nadal is the greatest player on clay of all-time. The 35-year-old Spaniard has won a record 13 French Open singles titles, seven more than the player with the next most in the Open era, Bjorn Borg. In 112 singles matches at Roland Garros, Nadal has lost just three times.

How to make Nadal vs. Djokovic picks

Calvert is leaning under 36.5 total games (+100), but he has two even stronger bets, including a prop that returns almost 2-1. Be sure to see Calvert's picks and analysis before making your French Open 2022 picks for the men's quarterfinal.

Who wins Nadal vs. Djokovic in the 2022 French Open men's quarterfinal? And what plus-money wager does Calvert like? Visit SportsLine now to see Sean Calvert's best bets for Djokovic vs Nadal, all from the tennis handicapper with a history of making big calls.