One woman will reach her first career grand slam final when American Jennifer Brady and Karolina Muchova of the Czech Republic collide in a semifinal of the 2021 Australian Open at Melbourne Park. The 25-year-old Brady is making her second career appearance in a grand slam semifinal. She reached the semis in last year's U.S. Open. Meanwhile, Muchova already has eclipsed her best career grand slam result; in 2019 she reached the quarterfinals at Wimbledon. Brady and Muchova will play after the first semifinal between Serena Williams and Naomi Osaka, which is set to begin at 10 p.m. ET on Wednesday. 

William Hill Sportsbook lists Brady as the -200 favorite, while Muchova is a +160 underdog. You can also pick whether Brady will cover a 3.5-game spread and how many sets the match will last, among other Brady vs. Muchova prop bets. Before making any Brady vs. Muchova picks, see the Australian Open 2021 predictions from elite tennis handicapper Gavin Mair.

Mair is the international women's tennis expert who called unseeded Jelena Ostapenko (80-1) winning the 2017 French Open, Osaka (32-1) winning the 2018 U.S. Open, Bianca Andreescu (20-1) winning the 2019 U.S. Open, plus many other spot-on calls. Before the women's singles final in the most recent Grand Slam, the French Open, Mair picked Iga Swiatek to win (-163) in straight sets (+140), and he was right on both counts as the 19-year-old beat Simona Halep for her first title.

In the 2021 Australian Open quarterfinals, Mair correctly called Brady to beat Jessica Pegula in three sets, which paid a handsome +275.

Now, Mair has broken down the latest 2021 Australian Open women's semifinal odds and released his coveted best bets for Brady vs. Muchova. He's sharing his analysis here.

Brady vs. Muchova preview

While the other semifinal between Williams and Osaka features the two biggest names in women's tennis, Muchova vs. Brady features two up-and-comers. Brady enters Wednesday's semifinal playing arguably the best tennis of her young career. This big-serving Floridian has hit 24 aces through her first five matches; only Williams and Osaka have hit more. She also enters the match a bit fresher than Muchova, having spent about two hours less on the court than her rival through the first 10 days.

Brady, however, hasn't faced the most difficult road to the semifinal. She has faced only one seeded player, No. 28 Donna Vekic, through her first five matches though Brady dispatched the 24-year-old Croatian rather easily, 6-1, 7-5. In meeting the 25th seeded Muchova, Brady faces her toughest test yet in Melbourne.

Like Brady, Muchova is playing her best tennis. A 24-year-old from the Czech Republic, Muchova turned pro in 2013 at age 17. She enjoyed little success until 2019, when she won her only WTA event, in Seoul, and reached the quarterfinals at Wimbledon. After starting that year ranked No. 144, she ended it ranked No. 21.

Muchova's best performance of 2020 came at the U.S. Open, where she beat Venus Williams, Anna Kalinskaya and Sorana Cirstea to reach her first round of 16. She entered the Australian Open ranked No. 27 and has knocked off three seeded players to reach her first career grand slam semifinal. In the quarterfinal match against Barty, Muchova was down a set and a break before rallying to win in three sets.

How to make Brady vs. Muchova picks

Will Brady roll through this round, or is Muchova positioned to pull off an upset? Mair has released a confident pick on the winner. Be sure to see Mair's analysis before making your Australian Open 2021 picks for the women's semifinal.

Who wins Brady vs. Muchova in the 2021 Australian Open women's singles semifinal? Visit SportsLine now to see Gavin Mair's best bets for Muchova vs. Brady, all from the acclaimed expert who hit big in the last Grand Slam women's final.