Offensive Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Quarterback | S. DarnoldSam Darnold | D. LockDrew Lock | |
| Running Back | K. Walker IIIKenneth Walker III | Z. CharbonnetZach Charbonnet | |
| Fullback | R. OuztsRobbie Ouzts | B. RussellBrady Russell | — |
| Wide Receiver | J. Smith-NjigbaJaxon Smith-Njigba | C. KuppCooper Kupp | |
| Tight End | A. BarnerAJ Barner | E. SaubertEric Saubert | |
| Left Tackle | C. CrossCharles Cross | M. RichmanMason Richman | — |
| Left Guard | G. ZabelGrey Zabel | C. HaynesChristian Haynes | |
| Center | J. SundellJalen Sundell | O. OluwatimiOlusegun Oluwatimi | — |
| Right Guard | A. BradfordAnthony Bradford | C. HaynesChristian Haynes | — |
| Right Tackle | A. LucasAbraham Lucas | J. JonesJosh Jones | — |
Defensive Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Left Defensive End | J. ReedJarran Reed | M. MorrisMike Morris | — |
| Nose Tackle | B. Murphy IIByron Murphy II | B. PiliBrandon Pili | — |
| Right Defensive End | L. WilliamsLeonard Williams | R. MillsRylie Mills | — |
| Left Inside Linebacker | D. ThomasDrake Thomas | T. KnightTyrice Knight | — |
| Right Inside Linebacker | E. JonesErnest Jones | P. O'ConnellPatrick O'Connell | |
| Strongside Linebacker | B. MafeBoye Mafe | U. NwosuUchenna Nwosu | |
| Weakside Linebacker | D. LawrenceDeMarcus Lawrence | D. HallDerick Hall | |
| Right Cornerback | T. WoolenTariq Woolen | J. JobeJosh Jobe | — |
| Left Cornerback | D. WitherspoonDevon Witherspoon | N. PritchettNehemiah Pritchett | — |
| Slot Cornerback | N. EmmanworiNick Emmanwori | — | — |
| Strong Safety | C. BryantCoby Bryant | A. FinleyAJ Finley | — |
| Free Safety | J. LoveJulian Love | T. OkadaTy Okada | — |
Special Teams Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Punter | M. DicksonMichael Dickson | — | — |
| Kicker | J. MyersJason Myers | — | — |
| Long Snapper | C. StollChris Stoll | — | — |
| Holder | M. DicksonMichael Dickson | — | — |
| Punt Returner | R. ShaheedRashid Shaheed | J. BoboJake Bobo | |
| Kick Returner | R. ShaheedRashid Shaheed | D. YoungDareke Young |