The AFC North and NFC West will get well acquainted with on Sunday, with three matchups between teams in those divisions. A Week 6 NFL parlay could combine NFL predictions for Browns vs. Eagles (-9.5), Ravens vs. Commanders (+6.5) and Bengals vs. Giants (+3.5). None of these matchups have taken place since 2020, and it has been eight years since the home teams last hosted their Sunday opponents. There may not be much to take away from the last meetings between these teams, which could make Week 6 NFL predictions more difficult.
However, you could still play the NFL betting trends with at least one of these game's total. Commanders vs. Ravens has the highest over-under (51.5) on the Week 6 NFL schedule, and both teams have seen the Over go 4-1 this season. So, backing that side of the total with your NFL parlay picks could be one leg of a potentially lucrative bet. Before you make any Week 6 NFL picks or NFL parlays, be sure to see what SportsLine senior analyst Larry Hartstein has to say.
A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed working for Pro Football Focus. Hartstein tied for 52nd place (out of 1,598 entries) in the 2022 Westgate Las Vegas SuperContest, going 53-34-3 ATS. His weekly Vegas contest selections form the basis of his NFL best bets column, which is 84-57-3 (59.6%, +20.90 units) since its inception in 2022.
For Week 6, Hartstein has locked in three confident best bets. If you successfully parlay his picks, you're looking at a payout of almost 6-1. You can only see Hartstein's Week 6 NFL picks at SportsLine.
Top Week 6 NFL picks
We can tell you Hartstein loves the Titans (-2.5) at home versus the Colts. "Over the last 42 plays of their loss to Jacksonville, the Colts gave up 419 yards, nearly 10 yards a play. This is the ultimate get-right spot for a Titans' offense that is sticking with Will Levis. He had the bye to reset and rest his injured shoulder," Hartstein told SportsLine.
Tennessee coming off a bye is notable as no team can match the Titans when it comes to post-bye spread success. The team is undefeated ATS over the last nine seasons following its bye, going 8-0-1, which includes both six straight covers and six straight outright victories. Additionally, the Titans are 5-2 over their last seven meetings with the Colts, and Indianapolis typically underperforms when at a rest disadvantage. As noted by Hartstein, the Colts gave the previously winless Jags their first victory last week, and Indianapolis is just 2-5 against the spread over its last seven games with a rest disadvantage. See which other NFL parlay picks to make here.
How to make Week 6 NFL parlays
Hartstein also jumped on two other NFL matchups that you need to see before constructing any NFL parlays. You can only see Hartstein's Week 6 NFL best bets and parlay at SportsLine.
What are Hartstein's top Week 6 NFL picks, and which NFL matchups should you target for an epic 6-1 payout? Visit SportsLine now to see the Week 6 NFL best bets from the Vegas expert who is up 20.90 units on NFL ATS picks, and find out.
