The top two scoring offenses in the league go head-to-head when the Buffalo Bills visit the Kansas City Chiefs during the Week 6 NFL schedule. Kansas City is producing a league-high 31.8 points per game, while Buffalo has averaged 30.4 over its first five games. The Bills also have been strong on the other side of the ball, as they are second in total defense (260.4 yards allowed) and tied for first in scoring defense (12.2 points allowed). Buffalo will have its hands full since Patrick Mahomes has thrown a league-high 15 touchdown passes, while tight end Travis Kelce leads the NFL with seven scoring catches. Which Week 6 NFL lines should you target with your Week 6 NFL bets? Before you make any Week 6 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model.
The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 6 of the 2022 NFL season on an incredible 146-106 run on top-rated NFL picks that dates back to the 2017 season.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.
Now, the model has locked in five confident NFL best bets for Week 6. If you successfully parlay its picks, you'd be looking at a massive payout of around 25-1. You can only see the model's Week 6 NFL picks at SportsLine.
Top Week 6 NFL picks
After simulating every game 10,000 times, the model is high on the New York Giants (+5.5) to cover against the Baltimore Ravens on Sunday. New York is coming off a 27-22 upset victory against Green Bay in London in which it overcame a 10-point halftime deficit by scoring on its first three second-half possessions. Saquon Barkley, who is second in the NFL with 533 rushing yards, snapped a 20-20 tie with the Giants' third touchdown run of the game with 6:08 remaining.
New York already has matched its victory total from last season in Brian Daboll's first year as head coach thanks in part to more responsible play from quarterback Daniel Jones. The sixth overall pick in the 2019 NFL Draft, Jones has committed only three turnovers thus far this year after being tied for third-most with 49 over his first three campaigns. That is one reason the Giants are covering the spread in well over 50% of simulations. See which other NFL parlay picks to make here.
How to make Week 6 NFL parlays
The model also jumped on four other NFL matchups where it says the line is way off, including backing a total that is off by a full touchdown. You can only see the model's NFL Week 6 best bets and parlay at SportsLine.
What are the model's top Week 6 NFL picks? And which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 6 NFL best bets from a model on a 146-106 run on its top-rated picks, and find out.
