The Saints have been strong offensively so far this season, averaging 45.5 points per game heading into their matchup against the Eagles on Sunday during the Week 3 NFL schedule. New Orleans shredded the Cowboys defense last week, as running back Alvin Kamara scored four touchdowns in a 44-19 win. He is facing a Philadelphia defense that gave up 97 rushing yards to Falcons running back Bijan Robinson last week, so should you back the Saints as 2.5-point home favorites with your Week 3 NFL bets and NFL parlay picks? Eagles vs. Saints has one of six Week 3 NFL spreads smaller than a field goal, so plenty of close games are expected.

The Week 3 NFL slate concludes with two Monday Night Football games, as Buffalo hosts Jacksonville and Cincinnati faces Washington. The Bills are 5-point favorites in the Week 3 NFL odds, while the Bengals are 7.5-point favorites. Before you make any Week 3 NFL picks or NFL parlays, be sure to see what SportsLine senior analyst Larry Hartstein has to say.

A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed working for Pro Football Focus. Hartstein tied for 52nd place (out of 1,598 entries) in the 2022 Westgate Las Vegas SuperContest, going 53-34-3 ATS. His weekly Vegas contest selections form the basis of his NFL best bets column, which is 81-51-3 (61.3%, +24.65 units) since its inception in 2022. He is 2-3-1 with his best bets this season, and anyone who has followed him is way up.

For Week 3, Hartstein has locked in three confident best bets. If you successfully parlay his picks, you're looking at a payout of over 6-1. You can only see Hartstein's Week 3 NFL picks at SportsLine.

Top Week 3 NFL picks

We can tell you Hartstein loves the Buccaneers (-6, 41) to cover against the Broncos. Denver has opened the season with losses to Seattle and Pittsburgh, as rookie quarterback Bo Nix has struggled to find his footing. He has a 35% completion rate and is averaging just 1.3 yards per attempt when pressured this season, and Tampa Bay has the second-highest blitz rate in the league through the first two weeks.

Buccaneers quarterback Baker Mayfield has completed 73.5% of his passes for 474 yards and five touchdowns, leading his team to wins over Washington and Detroit. Wide receivers Chris Godwin and Mike Evans continue to be elite weapons, while rookie running back Bucky Irving is averaging 5.3 yards per carry. Tampa Bay should dictate the pace of this game, and its defensive pressure is one key reason why Hartstein is taking the Bucs to cover. See which other NFL parlay picks to make here.

How to make Week 3 NFL parlays

Hartstein also jumped on two other NFL matchups, including backing one "desperate" team coming off a loss to grind out a strong Week 3 victory. You can only see Hartstein's Week 3 NFL best bets and parlay at SportsLine

What are Hartstein's top Week 3 NFL picks, and which other NFL matchups should you target for a strong 6-1 payout? Visit SportsLine now to see the Week 3 NFL best bets from the Vegas expert who is up 24.65 units on NFL ATS picks, and find out.