The Cleveland Browns and Pittsburgh Steelers had two of the worst opening games of the 2019 NFL season. While three fourth-quarter Baker Mayfield picks turned a tight game into a 43-13 win for the visiting Tennessee Titans, the Steelers were never competitive while turning in a 30-point loss to the New England Patriots. 

Along with those predicting the outcome of their games, we'll also predict how New England looks in Miami, two old Super Bowl rematches and arguably the most underrated game heading into this weekend. 

Pete Prisco and R.J. White joined Will Brinson on the Friday edition of the Pick Six Podcast to break down the gambling angles on all the games and give their best bets. Give it a listen below and be sure to subscribe:

Tampa Bay (0-1) at Carolina (0-1) 

Thursday, 8:20 p.m. ET (NFL Network) 
Point spread: Carolina -6.5

Carolina nearly upset the defending champion Los Angeles Rams in Week 1 after trailing by 13 points on two different occasions. While Christian McCaffrey, who amassed over 200 all-purpose yards and two touchdowns against the Rams, should have a tougher time against a Tampa Bay defense that allowed the San Francisco 49ers to average just 3.1 yards per carry last Sunday, no one should be picking the Buccaneers to win anything until Jameis Winston (20-of-36 passing with one touchdown and three picks last week) proves that he is an above average NFL starting quarterback. 

Prediction: Panthers 20, Buccaneers 16

Result: Buccaneers 20, Panthers 14

What picks can you make with confidence in Week 2? And which Super Bowl contender goes down hard? Visit SportsLine to see which NFL teams are winning more than 50 percent of simulations, all from the model that is up over $7,000 on its top-rated NFL picks. 

San Francisco (1-0) at Cincinnati (0-1)

Sunday, 1 p.m. ET (FOX) 
Point spread: Bengals -2

After an impressive opening-season victory in Tampa Bay, San Francisco will now face a Bengals team that saw quarterback Andy Dalton throw for 418 yards and two scores in a one-point loss in Seattle. The Bengals, who lost two Super Bowls against the 49ers in the 1980s, get their first victory of the season against a San Francisco team that will likely be without running back Tevin Coleman, who is currently dealing with a left high ankle sprain. 

Prediction: Bengals 24, 49ers 17

Los Angeles Chargers (0-1) at Detroit (0-0-1) 

Sunday, 1 p.m. ET (FOX)
Point spread: Chargers -2.5

While both teams squandered big leads in Week 1, the Chargers were able to hold on for a close victory over the Indianapolis Colts behind a big game by running back Austin Ekeler (154 all-purpose yards and three touchdowns). Look for Ekeler, Philip Rivers and the rest of the Chargers to outlast a Lions team that squandered a 17-point lead to the Arizona Cardinals in Week 1. 

Prediction: Chargers 31, Lions 27

Minnesota (1-0) at Green Bay (1-0)

Sunday, 1 p.m. ET (FOX)
Point spread: Packers -2.5

Both teams enjoyed stellar defensive performances in Week 1, with Green Bay's defense bailing out a lackluster offense in the Packers' season-opening win over the Chicago Bears. While Aaron Rodgers and Green Bay's offense will have a better outing this Sunday, the Vikings will outplay the Packers on both sides of the ball while getting their second victory of the season. 

Prediction: Vikings 19, Packers 16

Indianapolis (0-1) at Tennessee (1-0) 

Sunday, 1 p.m. ET (CBS) 
Point spread: Titans -3 

Just about everyone (me included) overlooked the Titans entering their season-opener in Cleveland against the Browns. With that in mind, I'm not making this same mistake this weekend. Let's see if the Titans can put together back-to-back winning performances while getting to 2-0 on the season. To do so, they'll have to beat a Colts team that nearly upset the Chargers in Week 1. 

Prediction: Titans 24, Colts 20 

New England (1-0) at Miami (0-1)

Sunday, 1 p.m. ET (CBS) 
Point spread: Patriots -19

It's safe to say that the Patriots aren't going to have the same issues in Miami on Sunday as they've historically had during the Bill Belichick-Tom Brady era. While maybe the Dolphins will play more inspired after allowing a whopping 59 points in their Week 1 loss to Baltimore, the Patriots, a week after dismantling the Steelers in Foxboro, will put forth another dominant effort in Miami. 

Oh, Sunday's game may also be Antonio Brown's debut as a Patriot. While he may not have a typical "AB" game, fans should expect Brown -- a Miami native -- to do something memorable in his first game with Brady and the Pats. Let's go with five grabs for 72 yards and a score for Brown, who is one of the many Patriots who will find the end zone in South Beach ... assuming his plays. If Brown is out, that's just more good news for fantasy football players who have Julian Edelman, Josh Gordon and Phillip Dorsett on their rosters. 

Prediction: Patriots 41, Dolphins 10 

Buffalo (1-0) at New York Giants (0-1)

Sunday, 1 p.m. ET (CBS) 
Point spread: Bills -2.5 

Our second way-back Super Bowl rematch is between two teams who appear to be heading in opposite directions. While the Giants put forth a listless Week 1 effort in Dallas, the Bills battled back to upset the Jets in New York. Buffalo keeps its momentum rolling against the Giants while "keeping pace" with the Pats in the AFC East race. 

Prediction: Bills 20, Giants 17

Seattle (1-0) at Pittsburgh (0-1) 

Sunday, 1 p.m. ET (FOX)
Point spread: Steelers -4 

Seattle is coming off a surprisingly close win over the visiting Bengals in Week 1, while the Steelers are looking to rebound after getting embarrassed in Foxborough. While Russell Wilson will make it tough, Pittsburgh starts to find its new offensive identity while getting to .500 through two weeks. 

Prediction: Steelers 23, Seahawks 20 

Dallas (1-0) at Washington (0-1)

Sunday, 1 p.m. ET (FOX)
Point spread: Cowboys -4.5

Dallas' impressive Week 1 showing has made it a considerable road favorite Sunday against a Washington team that made things close in Philadelphia last Sunday. While the Redskins will fight, their lack of offensive balance (Washington rushed for less than 30 yards against Philadelphia) will be one of the biggest reasons why the more balance Cowboys take care of business in D.C. 

Prediction: Cowboys 38, Redskins 27

Arizona (0-1-1) at Baltimore (1-0)

Sunday, 1 p.m. ET (FOX)
Point spread: Ravens -13.5 

This game features two young quarterbacks who impressed in Week 1 in Baltimore's Lamar Jackson and Arizona rookie Kyler Murray, who threw for 308 yards and two scores in his regular-season debut. While Murray will fight, he will be no match for a Ravens' defense that allowed just 200 yards in their Week 1 thrashing of Miami. 

Prediction: Ravens 34, Cardinals 17

Jacksonville (0-1) at Houston (0-1)

Sunday, 1 p.m. ET (CBS)
Point spread: -8.5 

The Jaguars not only surrendered 40 points to the Chiefs in their season-opener, they also lost Nick Foles for the foreseeable future after he sustained a broken clavicle. While rookie Gardner Minshew put forth an encouraging effort in relief of Foles, I don't see Jacksonville defeating a more talented Houston team on its home turf. 

Prediction: Texans, 31-20

Kansas City (1-0) at Oakland 

Sunday, 4:05 p.m. ET (CBS)
Point spread: Chiefs -8

While he won't have Tyreek Hill, Patrick Mahomes (25-of-33, 378 yards and three touchdowns last week) will still have enough weapons to light up the scoreboard against Kansas City's old AFL rival. Fantasy football owners can expect another big game from Sammy Watkins, who racked up 198 receiving yards and three touchdowns against the Jags. 

Prediction: Chiefs 41, Raiders 24

Chicago (0-1) at Denver 

Sunday, 4:25 p.m. EST (FOX)
Point spread: Bears -2.5

The Bears are coming off a disparaging effort at home to the Packers, while new Broncos head coach Vic Fangio prepares to go against his former team. While Chicago probably has the better team, Denver has the better QB in Joe Flacco (yes, that's an accurate statement), who wins his first home game as the Broncos' starting quarterback. 

Prediction: Broncos 16, Bears 13 

New Orleans (0-1) at Los Angeles Rams (1-0)

Sunday, 4:25 p.m. ET (FOX)
Point spread: Rams -2.5

Arguably the best game of the weekend, the Rams outlast a motivated Saints team that is out to prove that they were the NFC's best team in 2018. They won't make that happen on Sunday, as Los Angeles gets to 2-0 after a pair of close wins. 

Prediction: Rams 38, Saints 31 

Philadelphia (1-0) at Atlanta (0-1)

Sunday, 8:20 p.m. ET (NBC)
Point spread: Eagles -2.5

While the Falcons will play well in front of their home crowd, Carson Wentz (28-of-39 for 313 yards and three touchdowns last week) and the Eagles make a statement on national TV while keeping pace with the Cowboys in the AFC East chase. Philadelphia's defense will have to step up after defensive tackle Malik Jackson sustained a "serious" foot injury on Sunday. 

Prediction: Eagles 24, Falcons 20

Cleveland (0-1) at New York Jets (0-1)

Monday, 8:15 p.m. ET (ESPN)
Point spread: Browns -6.5

After initially picking the Jets to win this one, I don't see New York being able to defeat Cleveland without starting quarterback Sam Darnold, who will miss the game as he battles mono. Le'Veon Bell is also less than 100 percent heading into this game, as the Pro Bowl back was slated to get an MRI on his shoulder. 

Prediction: Browns 24, Jets 13