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Two last-place teams will battle when the Denver Broncos visit the Carolina Panthers in Week 12. Denver's visions of contention after the acquisition of Russell Wilson are up in smoke. Denver has been propped up by its defense, one of the best units in the NFL. The Broncos are allowing just 302.1 yards per game, the third-best mark in the sport. Carolina's own quarterback acquisition, Baker Mayfield, has played so poorly that it'll be Sam Darnold under center on Sunday. The Broncos are one-point favorites in the latest Week 12 NFL odds at Caesars Sportsbook. Which Week 12 NFL lines should you target with your Week 12 NFL bets? Before you make any Week 12 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 12 of the 2022 NFL season on an incredible 155-109 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has locked in five confident NFL best bets for Week 12. If you successfully parlay its picks, you'd be looking at a massive payout of around 25-1. You can only see the model's Week 12 NFL picks at SportsLine.

Top Week 12 NFL picks

After simulating every game 10,000 times, the model is high on the Seattle Seahawks (-4) to cover against the Las Vegas Raiders. The Raiders are allowing the highest opposing passer rating in the NFL, which is positive news for Geno Smith.

Smith, a longtime journeyman, has burst onto the scene this year. Smith's 108 passer rating is the second-best in the league, trailing only Miami's Tua Tagovailoa. The Raiders' porous passing defense should afford Smith plenty of opportunities to get the ball to Tyler Lockett and DK Metcalf and eat up chunks of the field. Both longtime Seattle fixtures have thrived with Smith under center, and that should remain the case with Las Vegas coming to town. That is one reason the Seahawks are covering the spread in over 50% of simulations. See which other NFL parlay picks to make here.

How to make Week 12 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including backing an underdog that is projected to win outright. You can only see the model's NFL Week 12 best bets and parlay at SportsLine. 

What are the model's top Week 12 NFL picks? And which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 12 NFL best bets from a model on a 155-109 run on its top-rated picks, and find out.