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The Indianapolis Colts (4-8-1) will visit the Minnesota Vikings (10-3) in a Saturday afternoon affair. Indianapolis leads the all-time series 18-7-1. Meanwhile, the contests between these clubs have been lopsided in recent memory. The Colts have won the last six games against Minnesota, while the last Vikings win against Indianapolis came in 1997. Both teams failed to cover last time out.

Kickoff is at 1 p.m. ET. Minnesota is favored by 3.5 points in the latest Colts vs. Vikings odds from Caesars Sportsbook, and the over/under is 47. Before making any Vikings vs. Colts picks, you need to see the NFL predictions and betting advice from the computer simulation model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 15 of the 2022 NFL season on an incredible 157-113 run on top-rated NFL picks that dates back to the 2017 season. The model is also a sizzling 21-5 on straight-up NFL picks over the past two weeks. 

The model ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Colts vs. Vikings and just locked in its picks and NFL predictions. You can head to SportsLine now to see the model's picks. Here are several NFL odds and betting lines for Colts vs. Vikings:

  • Colts vs. Vikings spread: Minnesota -3.5
  • Colts vs. Vikings Over-Under: 47 points  
  • Colts vs. Vikings money line: Minnesota -195, Indianapolis +162
  • MIN: Vikings are 8-2 against the spread in their last 10 games in Week 15 
  • IND: Colts are 5-1 ATS in their last six Saturday games 
  • Colts vs. Vikings picks: See picks here

Why the Vikings can cover

Running back Dalvin Cook is a dynamic and electric ball-carrier. Cook has excellent vision and runs with anticipation and elusiveness. The Florida State product is sixth in the NFL in carries (213) and rushing yards (950), but is tied for 10th in rushing touchdowns (eight). Cook logged 70-plus rush yards in nine games thus far.

Tight end T.J. Hockenson provides Minnesota with a big target over the middle. Hockenson is able to gain yards after the catch with a pair of reliable hands. The Iowa product and former Detroit Lion has reeled in 62 passes for 697 yards and four touchdowns. Adam Thielen is a possession receiver with outstanding body control. Thielen has a strong understanding of coverages and how to create space. He's caught 63 balls for 645 yards and four touchdowns. The two-time Pro Bowler has recorded 60-plus yards in two of the last three games. See which team to pick here.

Why the Colts can cover

Indianapolis has a stout pass defense, limiting the explosive plays downfield. The Colts head into this game ranked third in pass defense (188.6). This unit has allowed fewer than 175 passing yards in seven of their last 10 outings. Linebacker Zaire Franklin is the engine of this group. Franklin has been an instinctive force that flies sideline-to-sideline.

The Syracuse product has 131 total tackles, but is fourth in the NFL in solo stops (79). He finished with double-digit tackles in four straight games. Fellow linebacker Bobby Okereke has plenty of speed and quickly diagnoses the play. Okereke can defend tight ends and running backs with no problem in open space. The 2019 third-round pick is second on the team in total tackles (108) and tied for 11th in solo stops (70). See which team to pick here.

How to make Colts vs. Vikings picks

SportsLine's model is leaning Over on the point total, projecting the teams to combine for 49 points. The model also says one side hits well over 50% of the time. You can only get the model's pick at SportsLine

So who wins Vikings vs. Colts on Saturday? And which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the Vikings vs. Colts spread you need to jump on, all from the model on a 157-113 roll on NFL picks, and find out.