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Kenny Pickett and the Pittsburgh Steelers (2-6) are set to host Andy Dalton and the New Orleans Saints (3-6) in a cross-conference NFL Week 10 matchup. The Steelers have their sights set on snapping a two-game losing streak and should be well rested coming off a bye in Week 9. Meanwhile, the Saints are looking to rebound from a 27-13 loss to the Baltimore Ravens on Monday Night Football. Reigning NFL Defensive Player of the Year T.J. Watt is set to make his return to action for the Steelers after missing most of the season with a knee injury.

Kickoff is at 1 p.m. ET. The latest Steelers vs. Saints odds from Caesars Sportsbook list this game as a pick'em, and the over/under is set at 39.5. Before making any Saints vs. Steelers picks, you need to see the NFL predictions and betting advice  from the proven simulation model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 10 of the 2022 NFL season on an incredible 151-108 run on top-rated NFL picks that dates back to the 2017 season. The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Steelers vs. Saints and just locked in its picks and NFL Week 10 predictions. You can head to SportsLine now to see the model's picks. Here are several NFL odds and betting lines for Saints vs. Steelers:

  • Steelers vs. Saints spread: Pick'em 
  • Steelers vs. Saints over/under: 39.5 points
  • Steelers vs. Saints money line: Pittsburgh -110, New Orleans -110
  • Steelers vs. Saints picks: See picks here

What you need to know about the Steelers

Pittsburgh has to be aching after a bruising 35-13 loss to the Philadelphia Eagles two weeks ago. Rookie QB Kenny Pickett had a memorable game, but not in the way you want to be remembered: besides failing to produce a single touchdown, he threw one interception and fumbled the ball once with only 191 yards passing.

Pittsburgh should benefit from the return of outside linebacker T.J. Watt. The 2021 NFL Defensive Player of the Year injured his knee in Pittsburgh's 23-20 win over the Cincinnati Bengals in Week 1 and has been out of action since. Watt's presence alone should make things much easier for the rest of the Steelers defense. Pittsburgh's success in this matchup may come down to how well they defend against Saints RB Alvin Kamara

What you need to know about the Saints

Meanwhile, the Saints came up short against the Ravens this past Monday, falling 27-13. No one had a standout game offensively for New Orleans, but it got one touchdown from TE Juwan Johnson. Dalton ended up with a quarterback rating of 84.0.

The Saints remain talented enough to play with and beat any team in the league on any given Sunday, but inconsistencies, particularly on the offensive side of the ball, have kept them from being considered a legitimate threat in the NFC. At 3-6, they are still alive in the NFC South, but they can't afford too many more losses. New Orleans will get back veteran receiver Jarvis Landry, who has been out since Week 4 with an ankle injury.

How to make Saints vs. Steelers picks

The model has simulated Steelers vs. Saints 10,000 times and the results are in. The model is leaning Over on the point total, and it also says one side of the spread hits over 50% of the time. You can only see the model's pick at SportsLine.

So who wins Steelers vs. Saints? And which side of the spread hits over 50% of the time? Visit SportsLine right now to find out which side of the Saints vs. Steelers spread you should be all over, all from the model on a 151-108 roll on its top-rated NFL picks, and find out.