The top contenders in the AFC West will meet during the Week 4 NFL schedule as Patrick Mahomes, Travis Kelce and the Kansas City Chiefs (3-0) take on Jim Harbaugh and the Los Angeles Chargers (2-1). Justin Herbert (ankle) is listed as questionable for Los Angeles, and that's a factor for why the Chargers are tied as the second-largest underdog in the Week 4 NFL odds at +7.5. The Chargers have won just one of their last 15 games straight-up as underdogs, so Harbaugh will try to orchestrate a stunner in his fourth game back in the NFL.
Other Week 4 NFL lines of note include Eagles (-1) vs. Buccaneers, Ravens (-2.5) vs. Bills and Packers (-3) vs. Vikings. Which of those matchups should target in your Week 4 NFL picks and Week 4 NFL score predictions? Before you make any Week 4 NFL picks, you need to see the NFL against the spread, over-under, and money line predictions powered by the self-learning SportsLine AI.
Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team's historical data and then quantitatively evaluating the strength of the opponent's defense by assigning a numeric value out of 100 called a matchup score.
Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see an A-rating on an over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.
In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. Last season, SportsLine's AI PickBot hit a whopping 1,674 4.5- and 5-star prop picks. Anyone who has followed it is way up.
For Week 4 NFL betting, the AI PickBot has evaluated the NFL odds and provided NFL betting predictions for all 16 games. You can only see the AI predictions for the Week 4 NFL schedule here.
Top Week 4 NFL AI picks
After analyzing every game in Week 4, the AI PickBot says the Jaguars cover as 5.5-point road underdogs against the Texans. The Texans were a trendy preseason Super Bowl pick, but they haven't gotten off to the cleanest start. They barely survived as favorites against the Colts and Bears and then got blown out 34-7 in Week 3 at Minnesota. Quarterback C.J. Stroud has seen his QB rating go down since his rookie season and is on an early pace to throw more interceptions and take more sacks than last year.
Jacksonville might be undervalued in this spot after it struggled in a spotlight game at Buffalo last week, losing 47-10. Looking back at the first two weeks, Jacksonville took Miami (with Tua Tagovailoa) and the Browns down to the wire. SportsLine AI projects that this game comes down to less than a field goal, creating value on the visitors in this spot. See its other Week 4 football predictions and football picks at SportsLine.
How to make Week 4 NFL picks
In addition, the AI PickBot has generated 11 other A-rated picks for Week 4. You need to see the AI PickBot's picks before making any Week 4 NFL bets of your own. You can only see them at SportsLine.
Who wins and covers each Week 4 NFL game, and which A-rated picks should you target? Visit SportsLine now to see the top NFL picks against the spread, over-under, and on money line, all from the brand-new SportsLine AI PickBot that nailed 1,674 top-rated picks last season.
