Patriots vs. Bills odds, picks, line, how to watch, live stream: Model reveals 2021 Week 16 NFL prediction

TV channel, NFL best bets, picks for Buffalo Bills vs. New England Patriots on CBS and Paramount+

By CBS Sports Staff

Dec 26, 2021 at 11:56 am ET • 2 min read

A heated AFC East rivalry is set to renew on Sunday when the New England Patriots host the Buffalo Bills at Gillette Stadium. First place in the AFC East is up for grabs, so both teams will be pulling out all the stops to secure the victory. The Bills enter Sunday's showdown fresh off a 31-14 victory over the Carolina Panthers, while the Patriots suffered a 27-17 setback against the Colts in their last outing. In select markets, you can stream the game on Paramount+.

Kickoff is set for 1 p.m. ET. Caesars Sportsbook lists New England as a one-point favorite in the latest Patriots vs. Bills odds, while the over-under for total points scored is 43.5. In select markets, Sunday's matchup can be seen live on CBS and streamed live on Paramount+ with their must-have Premium plan.

Paramount+ now has levels of membership so you can watch your local NFL on CBS matchups and much more. The Premium Plan is $9.99 per month and you can watch your local CBS live stream, including plenty of sports like SEC on CBS, NFL on CBS, and the PGA Tour, with no ads, on demand and the ability to download episodes for offline viewing. Both plans come with a free week to start and include the NFL on CBS, so sign up now here.

How to watch Patriots vs. Bills

Patriots vs. Bills date: Sunday, Dec. 26
Patriots vs. Bills time: 1 p.m. ET
Patriots vs. Bills TV channel: CBS
Patriots vs. Bills live stream: Paramount+

Week 16 NFL picks for Bills vs. Patriots

Before you tune in to Sunday's Bills vs. Patriots game, you need to see the NFL picks from SportsLine's advanced computer model. The model, which simulates every NFL game 10,000 times, is up over $7,000 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 16 of the 2021 season on an incredible 133-96 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

For Bills vs. Patriots, the model predicts the under (43.5) hits with room to spare. These two teams combined for just 24 points in their first meeting this season. Weather certainly played a factor in that matchup, but both defenses have been playing extremely well all season long.

The Patriots feature the NFL's top-ranked scoring defense, giving up just 16.2 points per game. The Bills are giving up 17.4 points per game, which ranks second in the NFL. Buffalo's defense is also holding its opponents to just 287.9 yards per game, the best mark in the league.

Plus, the total has stayed under the total in five of New England's last six games played in December. SportsLine's model is predicting these two teams combine for 41 points, which helps the under hit in nearly 60 percent of simulations.