NFL odds, lines, picks, spreads, best bets, predictions, office pool, best survivor picks for Week 12, 2022

SportsLine's model locked in its Week 12 NFL predictions, NFL survivor picks and NFL office pool picks

By CBS Sports Staff

Nov 27, 2022 at 9:25 am ET • 4 min read

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The Tennessee Titans have won seven of their last eight games after beating the Packers on the road last week. Running back Derrick Henry had a standout day against Green Bay, rushing 28 times for 87 yards and a touchdown. The Titans are comfortably in first place in the AFC South with a 7-3 record, but they're 2.5-point underdogs at home against the Cincinnati Bengals according to the Week 12 NFL odds at Caesars Sportsbook, one of the slimmest NFL spreads of the week. Should your Week 12 NFL bets include the Titans to cover the spread or pull off the upset victory at home? Which NFL office pool picks and NFL survivor pool picks should you target? All of the Week 12 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and predictions you need to make the best Week 12 NFL picks now.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 12 of the 2022 NFL season on an incredible 155-109 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, it has turned its attention to the latest Week 12 NFL odds and locked in picks for every NFL matchup. Head here to see every pick.

Top Week 12 NFL predictions

One of the model's strongest Week 12 NFL picks is that the Seahawks (-4) cover the spread at home against the Raiders. Seattle has been one of the biggest surprises in the NFL after trading Russell Wilson to the Broncos this offseason. The Seahawks boast a 6-4 record and have won three of their four home games this season.

Seattle's rookie running back, Kenneth Walker III, has been extremely effective in recent weeks, rushing for at least 97 yards in three of his last five outings. He's also scored at least one touchdown in five of his last six games. Meanwhile, the Raiders are giving up 370.5 yards per game on defense, which ranks 27th in the NFL. SportsLine's model expects Walker will have another big day against the Raiders, projecting he'll average 4.7 yards per carry. Seattle covers more than 60% of the time, making it one of the Week 12 NFL best bets. See which other teams to pick here.

Top Week 12 NFL survivor picks

The model's Week 12 NFL knockout pool picks say to avoid the Broncos, even though they are favorites over the Panthers. Carolina is turning to Sam Darnold under center and hasn't gotten a TD pass from a starting quarterback since Week 8. He will make his season debut against a team whose offense is unequivocally the worst in the NFL, as Denver is averaging the fewest points (14.7).

The Broncos have not won a game in an opponent's stadium all season, going 0-4 in true road contests. All three of Carolina's wins have come at home, where it has a positive point differential, a positive turnover differential and has won its last two games, both by double-digits. Denver just cut leading rusher Melvin Gordon, while wide receiver Jerry Jeudy (ankle) is unlikely to play, further hampering the Broncos' struggling offense. The model foresees another dispirited showing by Denver's offense, and it advises you to look elsewhere with Week 12 NFL knockout pool picks. See which team you should pick here.

Top Week 12 NFL office pool picks

One of the strongest Week 12 NFL football pool picks from the model is that the Buccaneers beat the Browns. Tampa may have found the solution to its run game in its last game, as the team rushed for a season-high 161 yards. Rookie Rachaad White carried the rock 22 times for 105 yards, which was nearly as many yards as he had in his first eight games combined (117). He got the start over Leonard Fournette, and the veteran still had a productive day in a reserve role with 57 yards and a score.

With White's emergence making the ground games of these two teams a closer to even, Tampa has the offensive edge. The Bucs are projected to score their second-most points of the season, and Tampa is forecasted to win in 60% of simulations. See which other teams to pick here.

How to make Week 12 NFL picks

The model has also made the call on who wins and covers in every other game on the Week 12 NFL schedule, and it also says a Super Bowl contender goes down hard. It's also backing a shocking team in its NFL survivor picks. You can only get every pick for every game at SportsLine.

So what NFL predictions, NFL pool picks, and NFL survivor picks can you make with confidence? And which Super Bowl contender goes down hard? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $7,000 since its inception, and find out.