The Rams' dominant 30-13 victory over the Seahawks was one of the biggest surprises of Week 1. Seattle losing at home coming off a 9-8 season was a shocker to fans who took them with their NFL office pool picks. The Rams are now eight-point underdogs to the 49ers in Week 2. Can they pull off another shocker for Week 2 NFL confidence pool picks? The 49ers will be selected with the majority of Week 2 NFL pool picks, so is it worth fading the majority and going with Sean McVay to pull an upset victory? Before you make your NFL predictions, you need to see the Week 2 NFL football pool picks from SportsLine's proven computer model.
The model, which simulates every NFL game 10,000 times, is up over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters the 2023 NFL season on an incredible 163-113 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 17-6 roll on top-rated NFL picks since Week 7 of last season.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.
Now, the model has simulated the entire Week 2 NFL schedule 10,000 times and generated its optimal NFL pick'em plays. Head to SportsLine to see them now.
Top Week 2 NFL office pool predictions
One of the top Week 2 NFL predictions from the model: The Tampa Bay Buccaneers (-2.5) comfortably beat the Chicago Bears at home. The Bears ended last season on a 10-game losing streak and didn't look any better to start the new season, suffering a 38-20 loss to the Packers in Week 1. They've lost seven games by at least two scores over their current 11-game losing streak, falling by an average margin of 13.5 points over that span.
Tampa Bay was one of the biggest unknowns entering this season after future Hall of Fame quarterback Tom Brady retired this offseason. Although many question Baker Mayfield's status as a NFL starting quarterback, he's been successful given his circumstances. Before going 2-8 last year with the Panthers and Rams, the Browns went 29-30 with Mayfield in his 59 games as a starter over four years. In comparison, Cleveland went 4-38 in their previous three seasons before drafting Mayfield No. 1 overall in the 2018 NFL Draft.
The Buccaneers shocked the Vikings with a 20-17 road victory in Week 1 and the duo of Mike Evans and Chris Godwin still form one of the best receiver pairings in the league. Jordan Love, who was another significant unknown entering his season, threw for 245 yards and three touchdowns and the Chicago defense allowed Green Bay to convert on nine of 16 third downs. The model projects Chicago's struggles to continue as the Buccaneers are winning on nearly 60% of simulations. See the rest of the model's Week 2 NFL pool picks here.
How to make Week 2 NFL office pool picks
The model also made the call on every other Week 2 NFL game and has strong picks for potentially close matchups like Texans vs. Colts and Patriots vs. Dolphins. It's also calling for several favorites to struggle more than they are expected to. You can only see all of the model's NFL pool picks here.
So who should you pick in every Week 2 NFL game, and which favorites should you avoid? Visit SportsLine now to get optimal NFL office pool picks, all from a proven computer model that has returned over $7,000 since its inception, and find out.
