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The NFL loaded up on non-conference matchups on Sunday, as nine of the 13 games feature AFC teams versus NFC teams. Malik Willis could start for his former team, as the Packers are 3-point road underdogs against Tennessee in the latest Week 3 NFL odds. The late afternoon slate has quarterback Skylar Thompson filling in for Tua Tagovailoa (concussion), with Miami as a 4.5-point road underdog in the NFL Vegas odds against Seattle. On Sunday Night Football, the Chiefs are 3-point road favorites in the NFL betting lines as Patrick Mahomes will make his first pro start in Atlanta.

With these interconference battles being unfamiliar NFL matchups, you could certainly utilize NFL betting advice with NFL office pool picks and NFL confidence pool picks. Before you make your NFL predictions, you need to see the Week 3 NFL football pool picks from SportsLine's proven computer model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 3 of the 2024 NFL season on an incredible 187-130 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 41-22 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Get football picks for every game from a proven NFL model

In Week 3, SportsLine's advanced computer model, which simulates every NFL game 10,000 times, is predicting the Seattle Seahawks (-4.5, 41.5) to win comfortably at home against the Miami Dolphins. Seattle is undefeated, while Miami has recently struggled against winning teams. Over their last 12 games versus teams with above .500 records, the Dolphins are just 3-9 straight-up. Many of those came with Tagovailoa under center, and the dropoff to Thompson has major ramifications on Miami's best player in Tyreek Hill.

The speedy wideout averages 107 receiving ypg with Tagovailoa as starting QB in Miami, compared to 74.2 ypg when he doesn't start. Additionally, Hill has zero receiving touchdowns in the five games in which Tagovailoa hasn't started since he joined the Dolphins. With Hill less of a threat, Seattle can focus its attention on Miami's running game, which is already limited with Raheem Mostert banged up. Add in the huge home-field advantage that the Seahawks have with Miami flying cross-country, and Seattle is forecasted to win in nearly 70% of simulations. See all of SportsLine's Week 3 NFL predictions here.

How to make Week 3 NFL office pool picks

The model also made the call on every other Week 3 NFL game and has strong picks for potentially close NFL matchups like Cowboys vs. Ravens, Steelers vs. Chargers and Saints vs. Eagles. It's also calling for an upset you won't want to miss. You can only see all of the model's NFL pool picks here.

So who should you pick in every Week 3 NFL game, and which upset should you be all-in on? Visit SportsLine now to get optimal NFL office pool picks, all from a proven computer model that has returned well over $7,000 since its inception, and find out.