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Two teams coming off dominant victories will meet on Sunday when Derek Carr and the New Orleans Saints visit Dak Prescott and the Dallas Cowboys. The Saints secured a 47-10 victory at home over the Carolina Panthers, while the Cowboys handled business on the road and knocked off the Browns, 33-17. The Saints are 10-4 in their past 14 meetings with the Cowboys, but New Orleans is just 2-8 in its last 10 games played in Week 2.

The latest Week 2 NFL odds list the Cowboys as six-point favorites at home, but should you include Dallas in your Week 2 NFL office pool picks? Dallas has won 16 of its last 17 games at home, meaning the Cowboys could be a popular selection for NFL confidence pool picks. Before you make your NFL predictions, you need to see the Week 2 NFL football pool picks from SportsLine's proven computer model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 1 of the 2024 NFL season on an incredible 184-130 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 38-22 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Get football picks for every game from a proven NFL model

We'll give you one team to consider backing during Week 2. SportsLine's advanced computer model, which simulates every NFL game 10,000 times, is predicting the Los Angeles Chargers (-5) win comfortably on the road against the Carolina Panthers on Sunday.

Carolina's defense was torched in the season opener, giving up 47 points to the New Orleans Saints. The Panthers gave up 180 rushing yards against New Orleans and now they'll face a Chargers offense that loves to establish the run.

The Chargers finished with 176 rushing yards in their victory over the Raiders, led by the effectiveness of running back J.K. Dobbins. The former Ohio State standout carried the ball 10 times for 135 yards and a touchdown. Dobbins had separate runs of 46 yards and 61 yards in the second half and SportsLine's model expects he'll be effective again in Week 2. According to the model, Dobbins will average 5.7 yards per carry as Los Angeles rushes for over 100 yards and controls the clocks, a big reason why the Chargers win outright in nearly 80% of simulations. See all of SportsLine's Week 2 NFL predictions here.

How to make Week 2 NFL office pool picks

The model also made the call on every other Week 2 NFL game and has strong picks for potentially close NFL matchups like Jaguars vs. Browns, Cowboys vs. Saints and Ravens vs. Raiders. It's also calling for two Super Bowl contenders to go down hard. You can only see all of the model's NFL pool picks here.

So who should you pick in every Week 2 NFL game, and which Super Bowl contenders should you avoid? Visit SportsLine now to get optimal NFL office pool picks, all from a proven computer model that has returned well over $7,000 since its inception, and find out.