Patrick Mahomes and the Kansas City Chiefs (4-2) head to Levi's Stadium to play Jimmy Garoppolo and the San Francisco 49ers (3-3) on Sunday afternoon. The all-time series is currently tied 7-7. Despite that, Kansas City has won the last two matchups, including a 31-20 victory in 2020. The 49ers enter Sunday's showdown averaging 20.3 points per game this season and they just traded for star running back Christian McCaffrey this week. He's expected to make his San Francisco debut on Sunday against the Chiefs.
Kickoff is set for 4:25 p.m. ET. Kansas City is a one-point favorite in the latest Chiefs vs. 49ers odds from Caesars Sportsbook, and the over/under is 49. Before making any 49ers vs. Chiefs picks, you need to check out the NFL predictions and betting advice from the SportsLine Projection Model.
The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 7 of the 2022 NFL season on an incredible 146-107 run on top-rated NFL picks that dates back to the 2017 season.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.
Now, the model has set its sights on Chiefs vs. Niners, and just locked in its picks and NFL predictions. You can visit SportsLine now to see the model's picks. Here are the NFL odds and betting lines for Niners vs. Chiefs:
- Chiefs vs. 49ers spread: Kansas City -1
- Chiefs vs. 49ers over/under: 49 points
- Chiefs vs. 49ers money line: San Francisco +105, Kansas City -125
- KC: Over is 6-1 in Chiefs' last seven road games
- SF: 49ers are 6-0 ATS versus teams with a winning record
- Chiefs vs. 49ers picks: See picks at SportsLine
Why the Chiefs can cover
Tight end Travis Kelce is a dynamic weapon across the field. Kelce owns a rare combination of size (6-foot-5, 250 pounds) and speed. He is a matchup nightmare and has a strong route tree. The seven-time Pro Bowler serves as the go-to weapon within the offense and is a strong red zone target. Kelce is tied for sixth in receptions (41), 10th in receiving yards (455), and first in touchdowns (seven).
JuJu Smith-Schuster is a sure-handed receiver for Kansas City. Smith-Schuster isn't afraid to run over the middle of the field and provide YAC opportunities. The USC product has a big and powerful frame that allows him to box out defenders. He is second on the team in catches (27) and receiving yards (370). Last week, he snagged five receptions for 113 yards and a score. See which team to back here.
Why the 49ers can cover
Deebo Samuel is such an exceptional playmaker. Samuel has superb versatility to line up at receiver and log some carries as a running back. The 2021 Pro Bowl selection is dangerous with the ball in his hands, constantly providing massive yards after catch opportunities. Samuel is leading the team with 345 receiving yards and two touchdowns. He also has 136 rushing yards, while averaging 5.9 yards per carry.
Receiver Brandon Aiyuk owns the speed and explosiveness to generate big plays. Aiyuk is a fluid route runner and can make plays happen after the catch. The Arizona State product can line up anywhere on the field and make an impact. He's reeled in 25 passes for 320 yards and three touchdowns. In his last outing, he caught eight passes for 83 yards and two scores. See which team to back here.
How to make 49ers vs. Chiefs picks
SportsLine's model is leaning Under on the point total. In fact, it's calling for 47 total points. It also says one side of the spread cashes well over 50% of the time. You can only see the model's pick at SportsLine.
So who wins Niners vs. Chiefs? And which side of the spread cashes well over 50% of the time? Visit SportsLine now to see which side of the 49ers vs. Chiefs spread to jump on, all from the advanced model that is up almost $7,000 on NFL picks, and find out.
