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Two teams that have struggled in recent weeks square off on Sunday when the Buffalo Bills host the Carolina Panthers. The Bills limp into Sunday's contest having lost four of their last six games. Carolina, meanwhile, has lost eight of its last 10, including three straight. 

Kickoff from Bills Stadium is set for 1 p.m. ET. Caesars Sportsbook lists Buffalo as a 14-point favorite in the latest Panthers vs. Bills odds, while the over-under for total points scored is 44. Before entering any Bills  vs. Panthers picks, you'll want to see the NFL predictions from the model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 15 of the 2021 season on an incredible 132-96 run on top-rated NFL picks that dates back to the 2017 season. 

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Bills vs. Panthers. You can head to SportsLine to see its picks. Here are several NFL betting lines for Panthers vs. Bills:

  • Bills vs. Panthers spread: Bills -14
  • Bills vs. Panthers over-under: 44 points

What you need to know about the Bills

The Bills enter Sunday's showdown averaging 382.9 yards per game this season, which ranks eighth in the NFL. Quarterback Josh Allen has been Buffalo's main playmaker, and he's coming off one of his best performances of the season. Last week against the Buccaneers, Allen completed 66.7 percent of his passes for 308 yards and two touchdowns, while also rushing for 109 yards and another score. 

Allen will look to lead Buffalo to a much needed win on Sunday, and the Bills have been hard to beat on their home field. In fact, Buffalo is 10-3 in its last 13 home games. Plus, the Bills are 8-1 against the spread in their last nine games against an opponent from the NFC. 

What you need to know about the Panthers

Carolina took a 29-21 hit to the loss column from Atlanta in Week 14. The Falcons returned a Cam Newton interception 66 yards for a TD. Newton has lost three consecutive starts since rejoining the Panthers this season. Newton passed for 178 yards and rushed for 47 yards and a TD. He was replaced twice by P.J. Walker

The Panthers lost their fifth consecutive home game. Carolina comes into Week 15 with the second fewest yards allowed per game in the league at 293. D.J. Moore (hamstring) is questionable for Sunday's game. 

How to make Bills vs. Panthers picks

The model is leaning over on the total, and it also has generated a pick that hits in over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Bills vs. Panthers? And which side of the spread hits more than 50 percent of the time? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks.