The 2024 season hasn't gone as planned for the San Francisco 49ers (6-9), but they'll still have a chance to play spoiler on Monday Night Football in Week 17 when they host the Detroit Lions (13-2). Detroit is still in a tooth-and-nail battle with the Vikings for the NFC North title and the No. 1 seed in the NFC playoff bracket, but the defense has been prone to disappointing outings. The Lions will take on a 49ers offense that ranks fourth in the NFL in yards per play (6.1) and there's the potential for fireworks in this primetime matchup. Detroit is a 3.5-point favorite and the over-under is 50.
Does that mean that you should target overs as you bet NFL player props for 49ers vs. Lions? The latest 49ers vs. Lions player props list Jared Goff's over-under for total passing yards at 249.5, while George Kittle's over-under for total receiving yards is 68.5. Before betting any NFL props for Monday Night Football or entering NFL predictions on sites like PrizePicks, you need to see the Lions vs. 49ers NFL prop predictions powered by SportsLine's AI PickBot.
Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each player prop. The AI predictions are determined by statistically learning from each player's historical data and then quantitatively evaluating the strength of the opponent's defense by assigning a numeric value out of 100 called a matchup score.
Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. SportsLine's AI PickBot has nailed 2,131 4.5- and 5-star prop picks since the start of last season.
For 49ers vs. Lions, NFL betting on Monday Night Football, the AI PickBot has evaluated the NFL player prop odds and provided Lions vs. 49ers prop picks for every available prop market. You can only see the AI player prop predictions for San Francisco vs. Detroit here.
Top NFL player prop bets for 49ers vs. Lions
After analyzing Lions vs. 49ers props and examining the dozens of NFL player prop markets, the AI PickBot says 49ers quarterback Brock Purdy goes over 254.5 passing yards (-118 at FanDuel). In fact, AI PickBot ranks the over as a 4.5-star play and projects him to finish with 293 passing yards on average, noting that he has gone over his passing yardage total in four of the last six games where he's played at home against a defense ranked in the top third of the league.
Purdy has thrown for at least 300 yards in two of his last three games and has averaged 8.3 yards per pass attempt this season. With San Francisco (+3.5) expected to be in a trailing position, the AI PickBot is expecting Purdy to be throwing often. It predicts that he attempts 33 passes on average and thinks he comfortably goes over against a Lions pass defense that ranks 27th in the NFL. See more NFL props here.
How to make NFL player prop bets for Detroit vs. San Francisco
In addition, the AI PickBot says another star sails past his total and has 13 other NFL props rated four stars or better. You need to see the AI PickBot's analysis before making any 49ers vs. Lions prop bets for Monday Night Football.
Which Lions vs. 49ers prop bets should you target for Monday Night Football? Visit SportsLine now to see the top 49ers vs. Lions props, all from the SportsLine AI PickBot that has nailed 2,131 top-rated picks since the start of last season.
