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A heated NFC East rivalry will renew on Sunday when the Dallas Cowboys host the Philadelphia Eagles. The Cowboys will be without starting quarterback Dak Prescott, who will reportedly undergo season-ending surgery for an injured hamstring. That bodes well for the Eagles, who have won just two of their past seven meetings against the Cowboys. The latest Week 10 NFL odds list the Eagles as 7.5-point favorites. The Week 10 NFL schedule also features divisional NFL matchups like Broncos vs. Chiefs (-7.5, 42) and Falcons vs. Saints (+3.5, 46.5). If you're looking for a big return on your sports betting investment, nailing Week 10 NFL score predictions can be a highly profitable NFL betting strategy. Using a computer model's Week 10 NFL score predictions can help you crush your Week 10 NFL bets. Before you make any Week 10 NFL picks, make sure you see what SportsLine's advanced computer model has to say

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 10 of the 2024 NFL season on an incredible 14-7 betting hot streak on top-rated NFL picks this year. Longer term, it is on a 195-136 roll on top-rated NFL picks that dates back to the 2017 season and a 49-29 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone following at sportsbooks and on betting apps has seen strong returns at their best sports betting app.

Now, the model has simulated every Week 10 game 10,000 times. You can only see the model's Week 10 NFL exact score predictions at SportsLine.

Top Week 10 NFL picks

After diving into every game on the Week 10 NFL schedule, the model is backing the Los Angeles Chargers (-8, 39) to beat the Tennessee Titans, 26-16, at home. Los Angeles is coming off a comfortable 27-10 road victory over the Cleveland Browns last week. Running back J.K. Dobbins continued his dominant play with 14 carries for 85 rushing yards and two touchdowns. Dobbins is averaging 4.9 yards per carry this season and has scored four rushing touchdowns over his past four games.

The Titans, meanwhile, suffered a humiliating 52-14 defeat against the Detroit Lions in their last road game. Tennessee has struggled mightily away from home, losing 13 of its previous 15 road games. In addition, the Chargers have won eight consecutive home games against the Titans. SportsLine's model is projecting Dobbins will finish with 16 carries for 72 yards on Sunday, while Los Angeles' defense records 3.49 sacks on average. See the model's other Week 10 NFL score predictions at SportsLine.

How to make Week 10 NFL score predictions

In addition, the model has locked in exact score predictions for this week's biggest matchups including Lions vs. Texans, Eagles vs. Cowboys and Steelers vs. Commanders. It's also calling for a surprising underdog to pull off a shocking upset, making this team a must-back. Nailing this result is key to making profitable Week 10 NFL picks. You can only see them at SportsLine

Who wins each Week 10 NFL game, and which surprising underdog pulls off a shocking upset? Visit SportsLine now to get the model's NFL Week 10 score predictions, all from the model on a 195-136 roll on top-rated NFL picks, and find out.