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A Central Division battle is on tap between the Indiana Pacers and the Detroit Pistons at 7 p.m. ET on Wednesday at Little Caesars Arena. Detroit is 3-10 overall and 1-5 at home, while Indiana is 6-9 overall and 2-7 on the road. Indiana swept the season series last year and also covered in two out of the three head-to-head matchups with Detroit.

This season, the Pacers are 8-7 against the spread while the Pistons are 5-8. Indiana is favored by 6.5-points in the latest Pistons vs. Pacers odds from Caesars Sportsbook and the over-under is set at 206. Before entering any Pacers vs. Pistons picks, you'll want to see the NBA predictions from the advanced computer model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $9,000 in profit on its top-rated NBA picks over the past three-plus seasons. The model enters Week 5 of the 2021-22 NBA season up over $900 on all top-rated NBA picks this season. It's also on a stunning 113-75 roll on top-rated NBA picks against the spread that dates back to last season. Anyone following it has seen huge returns.

Now, the model has set its sights on Pistons vs. Pacers. You can head to SportsLine to see its picks. Here are several NBA betting lines for Pistons vs. Pacers:

  • Pistons vs. Pacers spread: Pistons +6.5
  • Pistons vs. Pacers over-under: 206 points

What you need to know about the Pistons

The Pistons found themselves the reluctant recipients of an unpleasant 129-107 punch to the gut against the Sacramento Kings on Monday. Detroit was in a tough position by the half, with the score already sitting at 68-44. Power forward Jerami Grant struggled in the loss. He played for 27 minutes but put up just seven points on 3-for-10 shooting.

After a breakout season where he averaged 22.3 points per game in 2020-21, Grant is averaging 17.9 points per game and his 40.9 percent shooting from the field is his worst since his rookie year in 2014-15 (35.2). However, No. 1 overall pick Cade Cunningham is finally starting to find his shooting stroke. He had 25 points in the loss to the Kings and is shooting 46.4 percent from the floor in his last four games.

What you need to know about the Pacers

Meanwhile, Indiana came up short against the New York Knicks on Monday, falling 92-84. The losing side was boosted by power forward Domantas Sabonis, who dropped a double-double with 21 points and 15 boards. Sabonis is averaging 18.5 points and 11.5 rebounds per game this season.

Malcolm Brogdon also had 22 points, eight rebounds and seven assists in the loss and had his first triple-double of the season earlier in the week against the 76ers. Brogdon is averaging 22.3 points, 7.3 rebound and 6.8 assists per game this season and his matchup with Cunningham should be an interesting one on Wednesday.

How to make Pistons vs. Pacers picks

The model has simulated Pistons vs. Pacers 10,000 times and the results are in. We can tell you that the model is leaning under, and it's also generated a point-spread pick that is hitting in almost 70 percent of simulations. You can only see the pick at SportsLine.

So who wins Pistons vs. Pacers? And which side of the spread hits in almost 70 percent of simulations? Visit SportsLine now to see which side of the Pacers vs. Pistons spread you need to jump on, all from the model that has crushed its NBA picks, and find out.