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On Wednesday, the San Antonio Spurs aim to stop the Western Conference's longest losing streak. San Antonio is 3-19 overall and 1-10 at home, entering a matchup against the Los Angeles Lakers with 17 straight defeats. Los Angeles is 14-10 overall and 4-8 on the road, with the Lakers playing on the second night of a back-to-back set. Anthony Davis (adductor/hip) and LeBron James (calf) are listed as questionable for Los Angeles.

For this game, SportsLine consensus lists the Lakers as 3-point favorites, and tip-off is scheduled for 8 p.m. ET. The total number of points Vegas thinks will be scored, or the over/under, is 231.5 in the latest Lakers vs. Spurs odds. Before making any Lakers vs. Spurs picks, you need to see the NBA predictions and betting advice from SportsLine's advanced computer simulation model.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit for $100 players on its top-rated NBA picks over the past five-plus seasons. The model enters Week 8 of the 2023-24 NBA season on a sizzling 97-51 roll on all top-rated NBA picks dating back to last season, returning more than $4,000. Anyone following it has seen huge returns.

Now, the model has set its sights on Lakers vs. Spurs and just locked in its picks and NBA predictions. You can head to SportsLine now to see the model's picks. Now, here are several NBA odds and betting lines for Spurs vs. Lakers:

  • Lakers vs. Spurs spread: Lakers -3
  • Lakers vs. Spurs over/under: 231.5 points
  • Lakers vs. Spurs money line: Lakers -151, Spurs +128
  • LAL: The Lakers are 0-4 against the spread with no rest this season
  • SA: The Spurs are 4-7 against the spread in home games
  • Lakers vs. Spurs picks: See picks at SportsLine

Why the Lakers can cover

Los Angeles recently completed an incredibly impressive run through the In-Season Tournament, going undefeated and hoisting the league's first-ever trophy in the event. The Lakers out-scored opponents by 19.0 points per 100 possessions in those seven games, and Los Angeles is also facing a Spurs team that is not performing at a high level in the aggregate. On defense, San Antonio is allowing 117.7 points per 100 possessions, and the Spurs are giving up 14.1 3-pointers per game and 38.9% shooting from 3-point range. San Antonio is also yielding almost 28 assists per game, and the Lakers keep consistent pressure on opponents by attacking the rim.

On offense, San Antonio is the league's worst team this season on a per-possession basis, scoring only 1.06 points per trip. The Spurs are also dead-last in free throw creation, with poor marks in field goal percentage, 3-point percentage, offensive rebound rate, and turnovers. Los Angeles has a strong overall defense, giving up only 1.11 points per possession, and the Lakers are No. 1 in free throw prevention, allowing only 19 attempts per game. See which team to pick here.

Why the Spurs can cover

Victor Wembanyama keys the Spurs, and the No. 1 overall pick is starring in his first NBA season. Wembanyama is averaging 18.8 points per game, leading San Antonio, and he is in the top 10 of the NBA with 10.6 rebounds per contest. Wembanyama is also one of the league's top rim protectors, averaging 2.8 blocked shots per game, and he is excelling with 19.3 points, 13.6 rebounds and 3.3 blocks per game over the last seven contests. San Antonio is in the top five of the NBA in averaging 28.8 assists per game, and the Spurs have the fewest shots blocked (3.7 per game) of any team in the league. 

The Lakers are also giving up more than 16 second-chance points per game, and Los Angeles is in the bottom third of the league in fast break points allowed. On the other end, the Lakers are dead-last in the NBA in second-chance points, with bottom-five marks in 3-pointers per game, 3-point accuracy, and offensive rebound rate. The Lakers are also committing nearly 15 turnovers per game. See which team to pick here.

How to make Lakers vs. Spurs picks

SportsLine's model is leaning Over on the total, projecting 239 combined points. The model also says one side of the spread hits in 60% of simulations. You can only see the model's picks at SportsLine.

So who wins Lakers vs. Spurs, and which side of the spread hits in 60% of simulations? Visit SportsLine now to see which side of the Lakers vs. Spurs spread you need to jump on Wednesday, all from the model on a 97-51 roll on top-rated NBA picks, and find out.