Rising heavyweight contender Tom Aspinall will headline in his hometown for the third consecutive time Saturday when he faces veteran Marcin Tybura in the main event of UFC Fight Night: Aspinall vs. Tybura. The five-round showdown that carries title-shot implications for the winner will anchor the main card starting at 3 p.m. ET from the O2 Arena in London. Aspinall shot up the UFC rankings behind five consecutive wins by finish to start his UFC career, but suffered a knee injury a year ago against Curtis Blaydes. He returns for another headlining appearance before his adoring hometown fans against the No. 10-ranked Tybura, who has won seven of his past eight to vault into title-contention.

Aspinall is a -490 favorite (risk $490 to win $100), while Tybura is priced at +360 in the latest UFC Fight Night: Aspinall vs. Tybura odds from Caesars Sportsbook. In the co-main event, another English fighter takes the spotlight when hometown favorite Molly McCann (-215) meets Julija Stoliarenko (+185) in a women's flyweight showdown. Before settling any UFC picks of your own for UFC Fight Night: Aspinall vs. Tybura, make sure you check out the MMA predictions and betting advice from SportsLine combat expert Daniel Vithlani.

Vithlani is a highly analytical UFC bettor who profited more than $6,200 for $100 bettors in 2022. This includes a documented 24-14 record on his well-respected, two-leg parlays. Every pick was documented on his public Instagram account.

From breaking down film and following fighters and their camps closely, to tracking sharp action and betting market signals, Vithlani covers the breadth of the MMA betting landscape top to bottom. He also trains amateur boxers and speaks regularly with MMA fighters to understand the sport's nuances.

In his SportsLine debut for UFC 283 in January, Vithlani swept the main card and his 5-0 record included advising SportsLine members to back Jamahal Hill (-125) against Glover Teixeira (+105) for the vacant light heavyweight title in the main event. Anyone who has followed him has seen massive returns.

Now, with UFC Fight Night: Aspinall vs. Tybura in sight, Vithlani has scoured the UFC fight card from top to bottom and released his top MMA picks. Vithlani's UFC Fight Night picks are only available at SportsLine. 

UFC Fight Night: Aspinall vs. Tybura preview 

Aspinall (12-3) made his UFC debut in July 2020 with a 45-second knockout of Jake Collier and soon emerged as one of the most prized heavyweight prospects in recent memory. He caught the attention of MMA observers because of his combination of speed, athleticism and expertise in a variety of disciplines.

Moreover, Aspinall quickly became a fan favorite because of his charismatic and gregarious demeanor away from the cage. The 30-year-old English fighter stopped his first five UFC opponents inside of two rounds while earning performance bonuses in four of them.

But in his first major litmus test against a top-five opponent, Aspinall suffered a torn MCL after attempting a leg kick just 15 seconds into the fight and suffered his first UFC defeat as a result. He makes his return Saturday in what most observers see as a favorable matchup against Tybura.

Tybura (24-7) is a seven-year UFC veteran who has squared off against some of the division's biggest names. The Polish fighter appeared headed toward journeyman status following a 4-5 start to his UFC career, even though most of his opponents were notable contenders.

His resume includes wins over former champion Andrei Arlovski and longtime contender Walt Harris, with losses to former champion Fabricio Werdum and former title challenger Derrick Lewis.

Behind a renewed dedication to training, Tybura launched his recent run of success starting with a win over Sergey Spivak in February 2020. The lone defeat in his last eight outings came against No. 7-ranked Alexander Volkov in October 2021. You can only see who to pick at UFC Fight Night here. 

Top UFC Fight Night predictions

We'll share one of Vithlani's UFC Fight Night predictions here: He is siding with Joshua Culibao (+120) to get past Lerone Murphy (-140) in a matchup of featherweight prospects.

Culibao (11-1-1) is a versatile and resilient fighter who has gone on a four-fight unbeaten streak since losing his debut to Jalin Turner, who is now ranked No. 12 at lightweight. The 29-year-old Australian is coming off a submission win against Melsik Baghdasaryan in February.

Murphy (12-0-1) is a power puncher and competent grappler who has reeled off four consecutive victories since settling for a draw in his UFC debut. The Manchester native kept his unbeaten record intact with a narrow split decision over Gabriel Santos in March.

"Culibao can throw unorthodox looks at Murphy and win moments wherever this fight goes with his nonstop activity. In what I expect to be a close and competitive three-round scrap, I'll take Culibao to edge out a decision," Vithlani told SportsLine. See who else to back here.

How to make UFC Fight Night picks

Vithlani also has strong picks for Aspinall vs. Tybura and other bouts on the UFC Fight Night card. He's backing a fighter who "has the potential to get a highlight KO win" to emerge with a dominant victory. See Vithlani's picks and analysis at SportsLine. 

Who wins UFC Fight Night: Aspinall vs. Tybura, and how exactly does each fight end? Visit SportsLine now to get detailed picks on every fight at UFC Fight Night: Aspinall vs. Tybura, all from the MMA expert who profited more than $6,200 in 2022, and find out.

UFC Fight Night odds, fight card

See full UFC Fight Night picks, predictions, best bets here.

Tom Aspinall (-490) vs. Marcin Tybura (+360)
Molly McCann (-215) vs. Julija Stoliarenko (+185)
Nathaniel Wood (-200) vs. Andre Fili (+170)
Makhmud Muradov (-325) vs. Bryan Barbarena (+255)
Ketlen Vieira (-165) vs. Pannie Kianzad (+140)
Chris Duncan (-150) vs. Yanal Ashmouz (+130)
Paul Craig (+190) vs. Andre Muniz (-225)
Jai Herbert (+135) vs. Fares Ziam (-155)
Lerone Murphy (-140) vs. Josh Culibao (+120)
Davey Grant (+120) vs. Daniel Marcos (-140)
Marc Diakese (+160) vs. Joel Alvarez (-190)
Michael Parkin (+125) vs. Jamal Pogues (-145)