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Sean Strickland and Dricus du Plessis have both promised an action-packed fight on Saturday when they meet in the main event of UFC 297. Their five-round showdown highlights the main UFC 297 fight card, which starts at 10 p.m. ET from Scotiabank Arena in Toronto. Strickland's first defense of his middleweight belt comes against a challenger with a similar straightforward, brawling style with sometimes optional defense. Strickland and du Plessis have repeatedly asserted this week that they won't take a backward step when the bell rings Saturday in the first UFC pay-per-view card of 2024. 

Strickland is a -130 betting favorite (risk $130 to win $100), while du Plessis is priced at +110 in the latest UFC 297: Strickland vs. Du Plessis odds. In the co-main event, the vacant women's bantamweight title is at stake when Mayra Bueno Silva (-175) takes on Raquel Pennington (+150). Before locking in any picks for UFC 297, make sure you check out the MMA predictions and betting advice from SportsLine expert Daniel Vithlani

From breaking down film and following fighters and their camps closely, to tracking sharp action and betting market signals, Vithlani covers the breadth of the MMA betting landscape top to bottom. He also trains amateur boxers and speaks regularly with MMA fighters to understand the sport's nuances. 

Vithlani made his SportsLine debut last January of last year and swept the main card for UFC 283 with a 5-0 record and has been a consistent winner ever since. At UFC 292 in August, he predicted the upset for underdog Sean O'Malley (+210) against Aljamain Sterling (-250) in the bantamweight championship main event. Anyone who has followed Vithlani already has seen massive returns. 

Now, with UFC 297: Strickland vs. Du Plessis in sight, Vithlani has studied the card from top to bottom and released his top picks and best bets. You can only see those picks at SportsLine

UFC 297: Strickland vs. Du Plessis preview 

Just a few short months ago, this matchup for the middleweight title would have been among the least-expected for MMA observers. Coincidentally, their divergent paths over the past year led to their meeting in Saturday's main event.

The bombastic Strickland (28-5) was climbing the rankings behind a six-fight winning streak before he was knocked out by Alex Pereira in a title eliminator in July 2022. This was followed by a split-decision loss to veteran contender Jared Cannonier that had seemingly relegated Strickland to the role of middleweight top-10 gatekeeper.

Meanwhile, du Plessis (20-2) was surging up the ranks behind a string of stoppage wins against notable contenders. The South African's upset knockout of former champion Robert Whittaker set the stage for a showdown with Adesanya, with whom there had been a budding rivalry. 

But du Plessis was unable to make UFC 293 because of a foot injury, and the promotion turned to Strickland in large part because he was the only notable contender who Adesanya hadn't already faced and defeated. Strickland was a nearly 7/1 underdog but used his brawling style to overwhelm Adesanya, nearly finishing the fight in the first round before capturing a dominant unanimous decision. 

Strickland was immediately matched for his first defense against du Plessis and, what started as a respectful interaction between the fighters, soon went off the charts with drama. At the UFC's "seasonal" press conference in December in which future fights are promoted, Strickland and du Plessis engaged in a memorable war of words. Just a few days later, they brawled in the stands at UFC 296 in Las Vegas, with UFC president Dana White later accepting blame for having the combatants seated just a row away from each other. You can see more UFC 297 picks at SportsLine.

UFC 297 predictions 

We'll share one of Vithlani's UFC 297 selections here: He is going with Mike Malott (-345) to get past Neil Magny (+275) in a welterweight showdown on the main card.

Magny (28-11) is an 11-year UFC veteran who is arguably one the promotion's most decorated fighters to have never competed for a title. Magny holds the record for most wins in the division's history with 21 and most appearances with 31. However, the 36-year-old Brooklyn native has gone 2-3 in his last five outings and has fallen into the role of top-10 gatekeeper.

Malott (10-1-1) is an explosive and versatile fighter who is widely regarded as the top Canadian prospect to come along in recent memory. The 32-year-old has won all three of his UFC outings inside of two rounds, with two submissions and one knockout.

"Malott has a distinct power advantage, and a fearless attitude that makes him feel like a safe pick even at these odds. The fans in Toronto will be thrilled to see the Canada native Malott secure another big win," Vithlani told SportsLine. You can see more UFC 297 picks at SportsLine.

How to make UFC 297 picks  

Vithlani has strong picks for Strickland vs. du Plessis and other bouts on the UFC Fight Night card. He's also backing a fighter who "feels like the more dominant fighter" to emerge with a dominant victory. Those picks are only available at SportsLine

Who wins UFC 297: Strickland vs. du Plessis, and how exactly does each fight end? Visit SportsLine now to get detailed picks on UFC 297, all from the MMA expert who profited more than $6,200 in 2022, and find out. 

UFC 297 odds, fight card

See full UFC 297 picks, predictions, best bets here.
Dricus du Plessis (+110) vs. Sean Strickland (-130)
Raquel Pennington (+150) vs. Mayra Bueno Silva (-175)
Mike Malott (-345) vs. Neil Magny (+275)
Chris Curtis (-195) vs. Marc-Andre Barriault (+160)
Arnold Allen (+165) vs. Movsar Evloev (-195)
Brad Katona (-190) vs. Garrett Armfield (+160)
Charles Jourdain (-190) vs. Sean Woodson (+160)
Serhiy Sidey (-175) vs. Ramon Tavares (+145)
Gillian Robertson (-245) vs. Polyana Viana (+200)
Jasmine Jasudavicius (-360) vs. Priscila Cachoeira (+285)