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The New York Yankees defeated the Cleveland Guardians 3-2 in the 2022 AL Divisional Series and now the 2023 MLB playoff hopefuls are going head-to-head in a three-game series early during this season. Cleveland took Game 1 by a final score of 3-2 thanks to a strong outing from Shane Bieber, who gave up two earned runs over seven innings in a win after falling behind 2-0 in the first. The Yankees walked nine batters in the loss but had only issued 25 free passes through their first nine games.

Tuesday's contest is slated to begin at 6:10 p.m. ET from Progressive Field in Cleveland, where the wind is expected to blow straight out at 14 mph to center field with temperatures in the mid-60s. New York is the -170 favorite (risk $170 to win $100) on the money line in the latest Guardians vs. Yankees odds from Caesars Sportsbook, while the over/under for total runs scored is 8. Before making any Yankees vs. Guardians picks, be sure to see the MLB predictions and betting advice from SportsLine's proven computer simulation model.

The SportsLine Projection Model simulates every MLB game 10,000 times. It went 331-285 on top-rated MLB money-line picks (+357) over the past two seasons, and it finished the 2022 MLB season on a 20-14 roll. Anybody who has followed it has seen profitable returns.

Now, the model has set its sights on Guardians vs. Yankees and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model's picks. Now, here are several MLB odds and betting lines for Yankees vs. Guardians:

  • Yankees vs. Guardians money line: Yankees -170, Guardians +143
  • Yankees vs. Guardians over/under: 8 runs 
  • Yankees vs. Guardians run line: Yankees -1.5 (+100) 
  • NYY: The Yankees have been favored in nine of their 10 games so far this season 
  • CLE: The Under is 6-2 in the Guardians' last eight matchups with the Yankees 
  • Yankees vs. Guardians picks: See picks at SportsLine

Why you should back the Yankees

New York will have its ace on the mound with Gerrit Cole taking the ball. Cole is 2-0 with a 0.73 ERA and has struck out 19 over 12 1/3 innings in his first two starts. He's also coming off a season where he was absolutely dominant against the Guardians.

Cole faced Cleveland on four occasions last season between the regular season and the MLB playoffs and he won all four times while giving up just five earned runs and striking out 31 over 26 innings. He's been sitting comfortably in the high-90s with his fastball early in the year and has staggering whiff rates of 50% with his slider and 63.6% with his changeup through two starts.

Why you should back the Guardians

Cleveland will counter with Hunter Gaddis, a 25-year-old righty who is 0-0 with a 3.72 ERA over 9 2/3 innings so far this season. The rookie had a 4.01 ERA between double-A and triple-A last season before earning a late-season call-up and made the club after an impressive spring where he had a 2.77 ERA and struck out 17 over 13 innings. 

The Cleveland lineup is built to get on base and run teams into trouble, with the Guardians leading the American League with 19 stolen bases this season. Five different players for the Guardians have at least a .364 OBP and five different players have stolen at least three bases so far this season.

How to make Yankees vs. Guardians picks

SportsLine's model is leaning Over on the run total, projecting the team to combine for 9.1 runs. It also says one side of the money line has all the value. You can only get the model's MLB picks at SportsLine.

So who wins Guardians vs. Yankees? And which side of the money line has all the value? Visit SportsLine now to see which side of the money line to jump on, all from the advanced model that finished last season on a roll, and find out.