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The Seattle Mariners look to halt their four-game losing streak and avoid a sweep when they visit the Chicago White Sox on Thursday afternoon for the finale of their three-game series. Seattle began the 2022 MLB season with a pair of one-run victories at Minnesota but has been outscored 23-10 while dropping its last four contests. Chicago reached reigning American League Cy Young Award winner Robbie Ray for six runs and 10 hits -- including three homers -- in posting its fourth consecutive win, a 6-4 triumph on Wednesday.

First pitch from Guaranteed Rate Field is set for 2:10 p.m. ET. Seattle is listed as a -120 favorite (risk $120 to win $100) on the money line in the latest Mariners vs. White Sox odds from Caesars Sportsbook, while the over-under for total runs scored is nine. Before making any White Sox vs. Mariners picks, be sure to check out the latest MLB predictions and betting advice from the SportsLine Projection Model.

This model, which simulates every game 10,000 times, enters Week 2 of the 2022 MLB season on a 216-181 roll on top-rated MLB picks that dates back to last season, returning over $900 for $100 players. Anyone following it has seen huge returns.

Now, the model has dialed in on White Sox vs. Mariners and revealed its predictions and best bets. You can visit SportsLine now to see the model's MLB picks. Here are the MLB odds and betting trends for Mariners vs. White Sox:

  • Mariners vs. White Sox money line: Seattle -120, Chicago +100
  • Mariners vs. White Sox over-under: 9 runs
  • Mariners vs. White Sox run line: Seattle -1.5 (+145)
  • SEA: The Mariners have yet to score more than four runs in a game this season
  • CWS: The White Sox are 9-2 in their last 11 games against right-handed starters

Why you should back the Mariners

Seattle is due to break out offensively as it has scored four runs or fewer in each of its first six contests this season. Ty France finally found his power stroke in Wednesday's loss as he belted his first home run of the year, a solo shot in the first inning that gave the Mariners a lead. The 27-year-old had a career year in 2021, hitting 18 homers and driving in 73 runs while posting a .291 batting average in his first full major-league season.

The Mariners' hottest hitter to start the campaign has been J.P. Crawford, who has gone 8-for-19 while reaching safely in every game. The 27-year-old shortstop collected three of Seattle's eight hits on Wednesday and drove in one run while scoring another. Manager Scott Servais is hoping to get another solid performance on the mound from right-hander Logan Gilbert, who allowed one run and three hits while registering seven strikeouts over five innings in a no-decision at Minnesota last Saturday in his first start of the season.

Why you should back the White Sox

Chicago has had no difficulty putting up runs this season, registering four or more in all but one of its five contests and has outscored its opponents 24-9 during its four-game winning streak. Eloy Jimenez -- who leads the team with seven RBIs -- is likely to miss the series finale after exiting Wednesday's game with an ankle contusion. But Andrew Vaughn has driven in six runs and gone deep twice while Luis Robert also has belted a pair of homers.

Vaughn has posted back-to-back two-hit performances and Tim Anderson has been solid at the plate after missing the first two games of the season. The AL batting champion in 2019, Anderson has recorded three-hit efforts in two of his three contests this year, including one on Wednesday in which he launched his first homer of 2022. Right-hander Jimmy Lambert will be making his season debut and proved he is capable of coming up with a solid outing as he allowed one run and three hits over five innings against Oakland en route to his first major-league victory in his final start of 2021.

How to make Mariners vs. White Sox picks

SportsLine's model is leaning over on the total, as the simulations have the teams combining for 9.1 runs. It also says one side of the money line has all the value. You can only get the model's pick at SportsLine.

So who wins White Sox vs. Mariners? And which side of the money line has all the value? Visit SportsLine now to see which side of the money line to jump on, all from the advanced model that has returned over $900 on top-rated MLB money-line picks dating back to last season, and find out.