One of baseball's most intense rivalries plays out Saturday afternoon when the Cubs host the White Sox in the second game of a three-game series. First pitch for this showdown from Wrigley Field is set for 2:20 p.m. ET. The Cubs are -261 on the money line, meaning it would take a $261 bet on the Cubs to return $100.

Before you make any kind of pick, you need to see what SportsLine's advanced computer has to say.

This model, which simulates every game 10,000 times, called for the Pirates (-110) to beat the White Sox straight-up on Thursday, but liked the White Sox on the run line (+1.5). The result was a 6-5 Pirates win that meant both picks cashed.

Now, the computer has simulated this matchup between the Cubs and White Sox and identified a strong money-line pick, which you can get only over at SportsLine.

The model knows that the South Siders' pitching has been terrible with a collective 5.25 ERA, while the Cubs have plenty of firepower in their lineup, including Kris Bryant, that could intimidate any hurler.

The White Sox are 9-26 for the season and 6-11 away from home, while the Cubs are 20-15 with an 11-6 record at Wrigley Field.

Taking the mound for the Cubs will be lefty Jon Lester, who's 2-1 with a 2.82 ERA. He's projected to strike out six White Sox batters in five innings of work. He'll oppose right-hander James Shields, who's 1-4- with a 5.14 ERA. The computer model is predicting Shields to strike out five Cubs in six innings.

So which side of the line should you be all over on Saturday? And where does the value lie? Visit SportsLine now to find out which side of the White Sox-Cubs money line you need to back, all from the computer model that simulates every game 10,000 times.