Phillies vs. Giants odds, line, score prediction, start time: 2024 MLB picks, May 6 best bets by proven model

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The Philadelphia Phillies will look to continue their torrid pace when they look to win their sixth game in a row and complete the four-game sweep over the San Francisco Giants on Monday. The Phillies (24-11), who have won 16 of 19 overall, have overtaken the Atlanta Braves for first place in the National League East. The Giants (15-20), who have dropped five of six overall, have lost five of their last six games at Philadelphia dating back to 2023. Philadelphia is 13-6 on their home field, while San Francisco is 6-13 on the road this season.

The game is slated to begin at 4:05 p.m. ET from Citizens Bank Park in Philadelphia. The Phillies have the fifth-best team batting average in MLB at .255, while the Giants are hitting .238, 16th-best. Philadelphia is a -227 favorite (risk $227 to win $100) on the money line in the latest Giants vs. Phillies odds from SportsLine consensus, while the over/under for total runs scored is 7.5. Before making any Phillies vs. Giants picks, be sure to see the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 7 of the 2024 MLB season on a profitable 115-91 run on top-rated MLB picks dating back to last season, and it has excelled on top-rated run-line picks during that span, going 20-8 (+708). Anybody following has seen huge returns.

Now, the model has set its sights on Phillies vs. Giants and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model's picks. Now, here are several MLB odds and betting lines for Giants vs. Phillies:

Phillies vs. Giants money line: Philadelphia -227, San Francisco +187
Phillies vs. Giants over/under: 7.5 runs
Phillies vs. Giants run line: Philadelphia -1.5 (-106)
SF: The Giants have hit the team total Under in 55 of their last 85 games (+22.17 units)
PHI: +554 on the money line in 2024
Phillies vs. Giants picks: See picks at SportsLine

Why you should back the Phillies

Philadelphia is expected to send right-hander Zack Wheeler (3-3, 1.91 ERA) to the mound and he'll be backed by a powerful lineup. Left fielder Brandon Marsh has a hit in all three games in the series and has driven in three runs. In 32 games this season, Marsh is batting .264 with two doubles, one triple, six homers and 20 RBI. He has hits in seven of the last 10 games, including a 3-for-5 effort with a double, homer and three RBI in a 9-3 win at San Diego on April 26. In nine career games against the Giants, he has driven in three runs.

First baseman Bryce Harper found his power stroke on Sunday night, popping a three-run home run in a 5-4 win over San Francisco. It was his first homer since April 26. For the season, he is hitting .234 with seven homers, 21 RBI and 17 runs scored. In 42 career games against the Giants, he is hitting .269 with five doubles, 10 homers and 28 RBI. See which team to pick here.

Why you should back the Giants

Right-hander Mason Black (0-0, 0.00 ERA) is expected to take the mound for San Francisco and make his big-league debut. He will be called up from Triple-A Sacramento to make the start. He has been solid at Triple-A, posting a 1.01 ERA and 0.92 WHIP with 29 strikeouts over 26.2 innings in six starts. He will start in place of Blake Snell (thigh) who remains unavailable.

Second baseman Thairo Estrada has been in a groove of late and enters Monday's action with a five-game hitting streak. In Sunday's loss, he was 1-for-3 with a homer and two RBI. He was 3-for-5 with an RBI and one run scored in Saturday's 14-3 loss. He had two hits with a double and two RBI in Friday's 4-3 defeat. In 34 games this season, Estrada is hitting .256 with seven doubles, one triple, five homers and 19 RBI. See which team to pick here.