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The San Diego Padres (40-24) and the Chicago Cubs (23-39) wrap up their three-game series on Thursday afternoon. San Diego has been playing well of late, winning seven of its last 10 games, including three straight wins. Meanwhile, Chicago has been in a slump, dropping nine games in a row. Joe Musgrove (7-0, 1.50 ERA) is starting for San Diego. Matt Swarmer (1-1, 4.24 ERA) is on the hill for Chicago. 

First pitch is set for 2:20 p.m. ET. Caesars Sportsbook lists San Diego as the -180 favorite (risk $180 to win $100) on the money line in the latest Padres vs. Cubs odds. Chicago is the +160 underdog and the over-under is set at 11 runs. Before making any Cubs vs. Padres picks, you need to see the MLB predictions and betting advice from SportsLine's advanced computer simulation model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a strong start to the 2022 season. It's on a 55-42 roll on top-rated MLB money-line picks through 10 weeks, returning over $600 for $100 players. Anyone following it has seen huge returns.

Now, the model has set its sights on Cubs vs. Padres, and just locked in its picks and MLB predictions. You can head to SportsLine to see its picks. Now, here are several MLB odds and betting lines for Padres vs. Cubs:

  • Cubs vs. Padres moneyline: San Diego -180, Chicago +160
  • Cubs vs. Padres run-line: San Diego -1.5 (-130)
  • Cubs vs. Padres over-under: 11 runs
  • Cubs vs. Padres tickets: See tickets at StubHub
  • SD: Padres are 6-0 in their last six vs. National League Central
  • CHC: Over is 5-1 in Cubs' last six vs. National League West

Why you should back the Padres

First baseman Eric Hosmer has shown his all-around ability. Hosmer can hit for average and owns a good glove in the corner. The four-time Gold Glove winner has home-run power but isn't overly aggressive. Hosmer is batting .284 with four home runs and 29 RBIs. On June 14, he went 1-for-3 with a single and two runs scored.

Musgrove has been dominant on the mound to kick off the season. Musgrove throws plenty of strikes and creates terrific movement on his pitches. The 29-year-old hasn't allowed more than two runs in any of his 11 starts thus far. Musgrove is tied for fifth in the majors in win-loss record (7-0), second in ERA (1.50), and seventh in WHIP (0.93). 

Why you should back the Cubs

First baseman Frank Schwindel has a nice, compact swing with home-run power. Schwindel is patient at the plate and won't go chasing pitches out of the strike zone. He currently leads the team in RBIs (32) with eight homers. On June 14, he went 2-for-4 with two singles and one RBI.

Catcher Willson Contreras is a smooth offensive producer for Chicago. Contreras is a reliable hitter with solid pitch recognition. The two-time All-Star can smack the ball all over the yard and constantly produce runs. Contreras leads the team in home runs (12) and on-base percentage (.398) while batting .277. On June 14, he went 3-for-4 with two homers and three RBIs. 

How to make Padres vs. Cubs picks

SportsLine's model is leaning under on the total, projecting 9.8 combined runs. It also says one side of the money line has all the value. You can only get the MLB model's picks at SportsLine.

So who wins Cubs vs. Padres? And which side has all the value? Visit SportsLine now to find out which side you need to jump on Thursday, all from the model that has crushed its MLB picks, and find out.