| Lance McCullers | Forearm | 04-30-2025Expected to be out until at least May 1 |
| Christian Walker | Oblique | 03-14-2025Questionable for start of season |
| Forrest Whitley | Knee | 03-26-2025Expected to be out until at least Mar 27 |
| Taylor Trammell | Calf | 03-26-2025Expected to be out until at least Mar 27 |
| Yainer Diaz | Illness | 03-13-2025Questionable for start of season |
| Kaleb Ort | Oblique | 03-26-2025Expected to be out until at least Mar 27 |
| Luis Garcia | Elbow | 05-01-2025Expected to be out until at least May 2 |
| Cristian Javier | Elbow | 07-19-2025Expected to be out until at least Jul 20 |
| Shawn Dubin | Shoulder | 04-17-2025Expected to be out until at least Apr 18 |
| J.P. France | Shoulder | 07-31-2025Expected to be out until at least Aug 1 |
| Pedro Leon | Knee | 04-17-2025Expected to be out until at least Apr 18 |
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