Cook (ankle) appears unlikely to play in Sunday's game against the Seahawks, according to Adam Schefter of ESPN.
The report notes that the running back, who didn't practice this past week, underwent treatment on his sprained ankle Saturday in the hope of giving it a go in Week 3, but at this stage it looks like the Vikings are preparing to turn to Alexander Mattison versus Seattle. For his part, Ian Rapoport of NFL Network suggests that even if Cook does end up suiting up for Sunday's 4:25 ET kickoff, he'd likely be very limited.