Mark Ingram couldn't have known that by midseason, he would be back to where his career began. After he was the lead option in Houston for seven games, he was traded to New Orleans and designated as the Saints' starter in Week 9. He's in for a bigger workload on Sunday because Alvin Kamara (knee) is out against the Tennessee Titans this week. How high should Ingram be in your Week 10 Fantasy football rankings?

The Titans' defense looks like an improved unit and allow up the eighth-fewest Fantasy points to running backs on a per-game basis. Ingram has just 28 yards on 12 carries in two games against the Titans, but should he be considered among the top Week 10 Fantasy football picks? Before you lock in your Week 10 Fantasy football lineups, be sure to check out the Week 10 Fantasy football rankings from the proven computer model at SportsLine.

When it comes to ranking players, SportsLine's model beat human experts in Fantasy football for the past several seasons especially when there were big differences in ranking. Over the course of a season, that could literally be the difference between winning your league or going home emptyhanded.

Last week, the model was extremely high on Chargers quarterback Justin Herbert, saying he'd finish as a top-10 player at his position. The result: Herbert threw for 356 yards and two touchdowns, while also rushing for 14 yards and another score against the Eagles. Anybody who had him in their lineup was well on their way to a huge week.

Now, the model, which simulates every NFL game 10,000 times, has revealed its Fantasy football rankings for Week 10 of the 2021 NFL season. Head to SportsLine now to see them.

Top Week 10 Fantasy football picks 

One player the model is high on this week: Cardinals running back James Conner. After co-starter Chase Edmonds was injured early on against San Francisco in Week 9, Conner took over the backfield. He finished the game with 21 carries for 96 yards and two touchdowns. He'll be the clear starter again this week, albeit in a potentially tougher matchup against Carolina.

The Panthers have given up just the seventh-fewest Fantasy points to running backs per game this season, but opponents have rushed for 534 yards against them over the last four weeks. Quarterback Kyler Murray has only accounted for 12 percent of the Cardinals' rushing yards this season, but Arizona has the seventh-most in the NFL. Conner should get plenty of volume against a defense that is a shell of its former self, which is why the model likes him as a top-ten option in its Fantasy football RB rankings.

And a massive shocker: Eagles quarterback Jalen Hurts, who's thrown for 1,981 yards and 11 touchdowns while also rushing for 494 yards and five scores, stumbles big-time and doesn't even crack the top 12 at his position. Hurts has thrown multiple touchdown passes four times this season, but he's struggled in recent weeks. In fact, Hurts has thrown one or zero touchdown passes in four of his last five games. He's also failed to record a rushing touchdown in his last three contests. 

Now, Hurts and the Eagles will face off against the Broncos, one of the NFL's stingiest defenses. Denver is giving up just 17.0 points per game this season, which ranks second in the league. Plus, the Broncos have given up just one passing touchdown to opposing quarterbacks in two of their last four games at home. With such a tough matchup on Sunday, Hurts is a player to consider putting on the bench in Week 10.

How to set Week 10 Fantasy football rankings

The model is also calling for a surprising quarterback you aren't even thinking about to finish in the top 10 of its Fantasy football rankings. This pick could be the difference between winning big and going home with nothing. You can only see who it is here.

So who should you start and sit this week? And which surprising quarterback could lead you to victory? Visit SportsLine now to get Week 10 Fantasy football rankings for every position, plus see which QB is going to come out of nowhere to crack the top 10, all from the model that has out-performed experts big-time.