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The New York Jets have faced several of the top quarterbacks in the Fantasy football rankings to begin the season, including Josh Allen and Patrick Mahomes. In both instances, the elite quarterbacks were held to their lowest scoring outputs of the season. The Jets will host Jalen Hurts and the Eagles on Sunday, so should you lower Hurts in the Week 6 Fantasy football QB rankings due to the matchup? It's tough to bench a quarterback the caliber of Hurts, but other quarterbacks could be higher-upside Fantasy football picks. Who would be better options to explore when forming Week 6 NFL Fantasy football lineups? Before you lock in your Week 6 Fantasy football lineups, be sure to check out the Week 6 Fantasy football rankings from the advanced computer model at SportsLine.

When it comes to ranking players, SportsLine's model beat human experts in Fantasy football for the past several seasons especially when there were big differences in ranking. Over the course of a season, that could literally be the difference between winning your league or going home empty-handed.

Now, the model, which simulates every NFL game 10,000 times, has revealed its Fantasy football rankings for Week 6 of the 2023 NFL season. Head to SportsLine now to see its Week 6 Fantasy football rankings.

Top Week 6 Fantasy football picks 

One player the model is high on this week: Vikings receiver Jordan Addison. Some rookie receivers struggle to quickly adapt and contribute to an NFL offense, but not Addison. The No. 23 overall pick in the 2023 NFL Draft had a touchdown in his two games, totaling seven receptions for 113 yards over those contests. Now, he'll be asked to assume even more of an offensive responsibility with Justin Jefferson (hamstring) placed on IR.

This will be the first game Jefferson has missed during his four years with the Vikings. However, it's safe to assume Minnesota will continue to throw often since Kirk Cousins ranks third in the NFL in passing yards (1,498) and was fourth last season in yards and attempts. Jefferson led the NFL in targets (184) last season and was averaging 11.8 targets through the first four games this year, so there are plenty of passes unaccounted for this week. Addison's 249 receiving yards is just five fewer than tight end T.J. Hockensen despite 10 fewer targets. Addison's usage should increase against the Bears, who are allowing the second-most passing yards per game (286) in the NFL this season.

And a massive shocker: Eagles wide receiver DeVonta Smith, who is coming off his first 1,000-yard season in 2022 and was started in 95% of CBS Sports Fantasy football leagues, stumbles big-time and doesn't even crack the top 25 at his position. He's a player to consider leaving out of your Week 6 Fantasy football lineups.

Smith made the Pro Bowl last season after catching 95 passes for 1,196 yards and seven touchdowns. He opened his season with double-digit Fantasy points in three of his first four starts. However, he was only targeted five times in Week 5 and finished with one catch for six yards. Despite leading the NFL in snap share (98.6%) and route participation (100.0%), Smith ranks 55th in target rate (19.7%). For more start/sit Fantasy football advice, be sure to check out the rest of the Week 6 Fantasy football rankings.

How to set Week 6 Fantasy football rankings

The model is also calling for an underrated running back to finish in the top five of its Fantasy football rankings, ahead of players like Derrick Henry and Alvin Kamara. These picks could be the difference between winning big and going home with nothing. See the Fantasy football QB, RB, WR, TE, defense and kicker rankings here.

So who should you start and sit this week, and which underrated running back could lead you to victory? Visit SportsLine now to get Week 6 Fantasy football rankings for every position and see which shocking running back comes out of nowhere to crack the top 10, all from the model that has outperformed experts big-time.