Aiyuk caught three of six targets for 91 yards in Sunday's 34-28 win over the Vikings.
He also gained four rushing yards on one carry. Deebo Samuel (groin) was doing most of his damage out of the backfield, leaving Aiyuk to lead the Niners in receiving yards while setting a new season high in the category. If Samuel's injury proves to be serious, Aiyuk will take on an even bigger role in Week 13 against the Seahawks.