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Castro is out of the lineup for the second game of Wednesday's doubleheader against the White Sox.
Kyle Farmer will get the nod at second base in the nightcap after Castro manned the keystone in the Twins' 3-1 loss in Game 1, going 0-for-3 with a walk. Castro is on the bench for the first time since June 20, ending a streak of 17 consecutive starts.