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Karcher was designated for assignment by the Reds on Thursday, Charlie Goldsmith of The Cincinnati Enquirer reports.
Tony Santillan (back/hamstring) has been activated off the 60-day injured list to fill the vacated 40-man roster spot. Karcher earned a save last month in his major-league debut, but he was sent back to Triple-A Louisville soon after and has struggled to a 7.18 ERA over 31.1 innings of relief this summer in the International League.
