De La Cruz suffered a left hamstring strain March 18 and will miss the start of the minor-league season, Charlie Goldsmith of the Cincinnati Enquirer reports.
The 21-year-old apparently suffered the injury shortly after being reassigned to minor-league camp in mid-March, and he has a tentative return date of April 12. De La Cruz is one of the top prospects in baseball, and he's poised to play for Triple-A Louisville once healthy after he posted a .947 OPS between the High-A and Double-A levels last year.