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Tellez will start at first base and bat seventh in Thursday's opener against the Athletics, Daniel Kramer of MLB.com reports.
The 30-year-old had appeared in line to handled designated hitter duties, but he will play first base instead while Luke Raley occupies the DH spot. Tellez is looking for a bounce-back 2025 season after he slashed only .243/.299/.392 in 131 games last year for the Pirates.