The No. 8 Oregon Ducks look to continue their standing at the top of the Pac-12 conference as they face the team at the bottom of the league, the Colorado Buffaloes on Saturday at Folsom Field in Boulder.  Oregon enters 7-1 following a 42-24 road win over Cal while the 1-7 Buffaloes lost to ASU last Saturday at home, 42-34. Last year the Ducks won a high-scoring matchup between the two teams, 52-29 in Eugene. Oregon is 5-2 against the spread, while Colorado is 2-6 ATS in 2022.

Kickoff is scheduled for 3:30 p.m. ET. The Ducks are favored by 31.5 points in the latest Oregon vs. Colorado odds from Caesars Sportsbook, and the over/under is set at 61.5. Before entering any Colorado vs. Oregon picks, you'll want to see the college football predictions and betting advice from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Colorado vs. Oregon and just locked in its picks and CFB predictions. You can head to SportsLine now to see the model's picks. Here are several college football odds and betting lines for Oregon vs. Colorado:

  • Oregon vs. Colorado spread: Oregon -31.5
  • Oregon vs. Colorado over/under: 61.5 points
  • Oregon vs. Colorado picks: See picks here

What you need to know about Oregon

The Ducks have been virtually unstoppable on offense since the 49-3 thrashing against No. 1 Georgia in their season opener. In their seven victories, the least amount of points Oregon generated was 41. And facing one of the nation's worst defenses this weekend probably will ensure that their streak of 41+ point games continues. In last week's convincing victory, senior QB Bo Nix threw for 412 yards and three scores, in what was his second 400+ passing yard output of the season. On the season, Nix has thrown for 2,221 yards with 20 TD passes and five interceptions, two of which happened last weekend against Cal. He's also run for 11 touchdowns on the season, including three last week against the Golden Bears. Quite simply, Nix has been elite since the Ducks' second game.

Other than Nix, RB Noah Whittington was the star for Oregon last week, rushing for 66 yards on 10 carries while catching five passes for 67 yards and a score. On the season, Whittington is second on the team in rushing yards with 475, trailing only Bucky Irving (568). The Ducks' leading receiver is sophomore Troy Franklin, who has 38 catches for 595 yards and five touchdowns. Kicker Camden Lewis has also been a standout, having not missed any of his 51 kicks, including eight field goals.

What you need to know about Colorado

The Buffaloes' season has been disastrous although the team has showed a spark under interim coach Mike Sanford Jr. that was missing under the departed Karl Dorrell. Colorado's defense is surrendering an average of 483.8 yards and 39.1 points per game, both third worst among all FBS teams. Opposing teams are averaging 237.3 yards on the ground against CU, which is second worst in the nation. 

On offense, Colorado showed some promise last week against the Sun Devils. J.T. Shrout's completion percentage wasn't great, 13 of 34, but he made his completions count, throwing for 222 yards and two touchdowns with one interception. Jordyn Tyson caught five passes for 115 yards and a touchdown while Deion Smith rushed 24 times for 111 yards and another score. For the game to be close on Saturday, Colorado must play mistake free football and hope for Oregon's offense to be as dysfunctional as it was against Georgia. Otherwise, a Ducks blowout appears likely.

How to make Oregon vs. Colorado picks

The model has simulated Colorado vs. Oregon 10,000 times and the results are in. We can tell you that the model is leaning Under on the point total, and it's also generated a point-spread pick that is hitting in more than 50% of simulations. You can only see the pick at SportsLine.

So who wins the Oregon vs. Colorado matchup? And which side of the spread hits more than 50% of the time? Visit SportsLine now to see which side of the Oregon vs. Colorado spread to jump on, all from the advanced model that finished the past six-plus years up almost $3,000 on its FBS college football picks, and find out.