NCAA Football: Florida at Tennessee
USATSI

SEC teams coming off big wins collide when the No. 7 Ole Miss Rebels take on the LSU Tigers in the SEC on CBS game on Saturday at Tiger Stadium in Baton Rouge, La. The Rebels (7-0, 3-0 in SEC) are riding high after rushing for 448 yards in a 48-34 victory over Auburn. They are looking to go 8-0 for the first time in 60 years. Meanwhile the Tigers (5-2, 3-1) are coming off their best performance of the season, a 45-35 win at Florida. Quarterback Jayden Daniels accounted for six touchdowns in that victory. 

Kickoff is 3:30 p.m. ET on CBS. The latest LSU vs. Ole Miss odds from Caesars Sportsbook list this game as a pick'em, while the over/under for total points scored is 64.5. Saturday's game can be seen live on CBS and streamed live on Paramount+ with their must-have Premium plan. 

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Before making any LSU vs. Ole Miss picks or college football predictions, see what SportsLine's advanced computer model has to say.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on LSU vs. Ole Miss and just locked in its picks and CFB predictions. You can visit SportsLine now to see its picks. Here are the college football odds and betting lines for Ole Miss vs. LSU:  

  • LSU vs. Ole Miss spread: Pick'em
  • LSU vs. Ole Miss over/under: 64.5 points
  • LSU vs. Ole Miss money line: Tigers -110, Rebels -110
  • LSU: QB Jayden Daniels ranks sixth in the SEC in total offense (281.0 yards per game).
  • MISS: The Rebels are third in the country in rushing offense (271.4 yards per game).
  • LSU vs. Ole Miss picks: See picks at SportsLine
  • LSU vs. Ole Miss streaming: Paramount+

Why LSU can cover

LSU has a dynamic playmaker in Kayshon Boutte. A 6-foot junior from New Iberia, La., Boutte has 106 receptions for 1,489 yards and 15 touchdowns in just three seasons in Baton Rouge. In the last meeting between LSU and Ole Miss in Tiger Stadium, he caught 14 passes for an SEC-record 308 yards and three touchdowns in a 53-48 win. And last week he had his best game of the season, with six receptions for 115 yards in the win over Florida.

In addition, Daniels can beat the Rebels with both his arm and his feet. Daniels has accounted for 16 touchdowns (10 passing, six rushing) and leads LSU in both rushing yards (403) and passing yards (1,564). He needs only one more rushing touchdown to tie the program record for rushing TDs (seven) by a quarterback.

Why Ole Miss can cover 

Ole Miss faces a LSU defense that has struggled recently. After giving up just 14.8 points a game over the team's first five games, the Tigers have allowed 35 points in each of the last two games, against Tennessee and Florida. They also have been gashed for 236.5 rushing yards a game over the last two weeks. That bodes well for a Rebels offense that ranks third in the country in rushing yards per game (271.4).

In addition, Ole Miss has done a good job recently taking care of business against unranked opponents. Since the start of last season, the Rebels are 14-0 against unranked foes. The average score in those games has been 41-19.

How to make Ole Miss vs. LSU picks

SportsLine's model is leaning Under on the total, with the teams projected to combine for 58 points. The model also says one side of the spread hits well over 60% of the time. Head to SportsLine to see the picks

So who will win LSU vs. Ole Miss? And which side of the spread hits well over 60% of the time? Visit SportsLine now to see which side of the spread to jump on, all from the model that has crushed its college football picks, and find out, and don't forget to stream the game on Paramount+.