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The Iowa Hawkeyes and Iowa State Cyclones are set to renew their Cy-Hawk Series rivalry on Saturday afternoon. This will be the 71st meeting in series history, a rivalry the Hawkeyes have dominated in recent years. Iowa has won seven of the past eight meetings against Iowa State, including a 20-13 victory last season in Ames. Iowa is coming off a 40-0 victory over Illinois State in its opener, while Iowa State secured a 21-3 win against North Dakota.

This matchup gets underway from Kinnick Stadium at 3:30 p.m. ET. The Hawkeyes are 2.5-point favorites in the latest Iowa vs. Iowa State odds from SportsLine consensus, while the over/under for total points scored is 36. Before making any Iowa State vs. Iowa picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

Saturday's game can be seen live on CBS and streamed live on Paramount+, which you can now get for 50% off your first year plus a 7-day free trial (valid through 9/22/24).

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of over $2,000 for $100 players on its top-rated college football picks against the spread. It is also coming off a profitable 13-9 season on top-rated spread picks. Anyone who has followed it has seen strong returns.

Now, the model has dialed in on Iowa vs. Iowa State and just revealed its coveted picks and predictions. You can head to SportsLine now to see the model's picks. Here are the college football odds and trends for Iowa State vs. Iowa:

  • Iowa State vs. Iowa spread: Hawkeyes -2.5
  • Iowa State vs. Iowa over/under: 36 points 
  • Iowa State vs. Iowa money line: Iowa -139, Iowa State +117
  • Iowa State vs. Iowa picks: See picks here
  • Iowa State vs. Iowa streaming: Paramount+ (get 50% off first year of annual plan now through 9/22/24)

Why Iowa can cover

Iowa featured one of college football's most stifling defenses last season, giving up just 14.8 points per game, the fourth-fewest in the nation. The Hawkeyes pitched a shutout in the season opener, beating Illinois State 40-0. Defensive lineman Aaron Graves finished with three sacks in the win, while Jermari Harris recorded the team's only interception.

Offensively, quarterback Cade McNamara was extremely effective, throwing for 251 yards and three touchdowns. Wide receiver Reece Vander Zee became the first Iowa player with multiple receiving scores in a game since 2020, catching five passes for 66 yards and two TDs. Running back Kaleb Johnson also racked up two rushing touchdowns and finished with 119 yards on 11 carries. See picks at SportsLine

Why Iowa State can cover

Iowa State has an extremely talented receiving corps that can get behind defenses quickly. Wide receiver Jaylin Noel had a team-high 66 receptions last season and he's recorded 172 career receptions, fifth-most in Iowa State history. WR Jayden Higgins is a big-play threat for the Cyclones. He finished with 214 receiving yards against Memphis last season, the second-most receiving yards in a game in Iowa State history.

The Cyclones also have a lot of talent on the defensive side of the ball. Jeremiah Cooper had five interceptions last season, which tied a program record. Myles Purchase finished with 15 passes defended last season, T-4th most in FBS. Purchase's 15 passes defended were the most by any Iowa State player in a season since at least 2005. See picks at SportsLine

How to make Iowa State vs. Iowa picks

SportsLine's model is leaning Under on the total, projecting 31 combined points. It also says one side of the spread hits more than 50% of the time. You can see the model's pick at SportsLine.

So who wins Iowa vs. Iowa State, and which side of the spread hits more than 50% of the time? Visit SportsLine now to see which side of the spread to jump on, all from the advanced model that is up well over $2,000 on top-rated spread picks since its inception, and find out, and don't forget to stream on Paramount+.