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The South Florida Bulls and the East Carolina Pirates are set to square off in an American Athletic matchup at 7 p.m. ET on Saturday at Raymond James Stadium. The Bulls are 1-2 overall and 1-0 at home, while East Carolina is 0-2 overall and 0-1 on the road. USF enters Saturday's matchup with a 1-6 record in its last seven games. The Pirates, meanwhile, are 2-12 in their last 14 games on the road. 

The Bulls are favored by six-points in the latest South Florida vs. East Carolina odds from William Hill, and the over-under is set at 57. Before entering any East Carolina vs. South Florida picks, you'll want to see the college football predictions from the proven computer model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past four-plus years, the proprietary computer model has generated a stunning profit of over $4,200 for $100 players on its top-rated college football picks against the spread. It is a sizzling 20-3 on top-rated picks through five weeks of the 2020 college football season, returning over $1,300 in profit already. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on South Florida vs. East Carolina. You can head to SportsLine to see its picks. Here are several college football odds for East Carolina vs. South Florida:

  • South Florida vs. East Carolina spread: South Florida -6
  • South Florida vs. East Carolina over-under: 57 points
  • South Florida vs. East Carolina money line: South Florida -215, East Carolina +185

What you need to know about South Florida

South Florida suffered a grim 28-7 defeat to the Cincinnati Bearcats in its last outing. The Bulls struggled mightily on offense, throwing a combined five interceptions against the Bearcats. The Bulls' only touchdown came from RB Johnny Ford.

Despite their most recent setback, the Bulls will enter Saturday's matchup confident they can secure the victory. That's because South Florida has had tremendous success against the Pirates in recent years. In fact, South Florida is 9-1 in its last 10 games against East Carolina.

What you need to know about East Carolina

The Pirates might not have won anyway, but with 123 yards lost due to penalties, they really shot themselves in the foot on Saturday. East Carolina took a hard 49-29 fall against the Georgia State Panthers. A silver lining for East Carolina was the play of wide receiver Tyler Snead, who punched in one rushing touchdown in addition to catching 11 passes for 111 yards.

East Carolina is averaging 28.5 points per game on offense, and the Pirates will look to take advantage of a porous South Florida defense on Saturday. The Bulls have given up 80 points in their last two games, which bodes well for an East Carolina offense that is averaging 375.5 yards per game. 

How to make East Carolina vs. South Florida picks

The model has simulated South Florida vs. East Carolina 10,000 times and the results are in. The model is leaning under on the total, and it's also generated a point-spread pick that is hitting in over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins East Carolina vs. South Florida? And which side of the spread hits over 50 percent of the time? Visit SportsLine now to see which side of the USF vs. ECU spread to jump on Saturday, all from the advanced model that is up over $4,200 on its top-rated college football spread picks, and find out.