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The Charlotte 49ers will take on the Duke Blue Devils at 7 p.m. ET on Friday at Jerry Richardson Stadium on CBS Sports Network. Both teams are looking to get back on track after frustrating 2020 campaigns. The Blue Devils went 2-9, their worst record since 2007. Charlotte battled numerous COVID-19 disruptions on its way to a 2-4 mark. 

The Blue Devils are favored by 6.5 points in the latest Charlotte vs. Duke odds from Caesars Sportsbook, and the over-under is set at 60.5. Before entering any Duke vs. Charlotte picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of over $3,600 for $100 players on its top-rated college football picks against the spread. It also enters Week 1 of the 2021 season on a 57-37 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Charlotte vs. Duke. You can head to SportsLine to see its picks. Here are several college football odds for Duke vs. Charlotte:

  • Charlotte vs. Duke spread: Duke -6.5
  • Charlotte vs. Duke over-under: 60 points

What to know about the Charlotte 49ers 

Coach Will Healy brought energy to the upstart program in 2019, guiding the 49ers to a 7-6 campaign and their first ever bowl appearance. Pandemic-related issues slowed that momentum in 2020 as Charlotte dealt with numerous game postponements and struggled to get any kind of momentum or cohesion as the schedule was constantly changing. 

The 49ers do return quarterback Chris Reynolds, but they lost a lot of production from the backfield. They'll need a better defensive effort this year as well after giving up 32.5 points per game in 2020. 

What to know about the Duke Blue Devils 

David Cutcliffe has done a masterful job overall at Duke, but the Blue Devils fell back into losing ways in 2020. The 2-9 campaign was Cutcliffe's worst at Duke and just his third overall losing season at a program that has historically struggled to contend in football in the ACC. 

Gunnar Holmberg takes over at quarterback and he'll lean on senior receiver Jake Bobo, who led the team in receiving last year. The Blue Devils, like the 49ers, struggled on defense last year, giving up a whopping 38.1 points per game, so that certainly was a point of emphasis this offseason. 

How to make Duke vs. Charlotte picks

The model has simulated Charlotte vs. Duke 10,000 times and the results are in. The model is leaning over on the total, and it's also generated a point-spread pick that is hitting in over 60 percent of simulations. You can only see the pick at SportsLine.

So who wins Charlotte vs. Duke? And which side of the spread is a must-back? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks